Detailed information of TA system TA093323

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1-StbC
• Location: 1591502..1592162
• Replicon: chromosome
• Accession: NZ_CP026105
• Organism: Paraburkholderia hospita strain DSM 17164

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: C2L64_RS07125
• Protein ID: WP_086916991.1
• Coordinates: 1591734..1592162 (+)
• Length: 143 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A7Z7B428
• Locus tag: C2L64_RS07120
• Protein ID: WP_007588356.1
• Coordinates: 1591502..1591747 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C2L64_RS07095	1587098..1587610	-	513	WP_090836035.1	Spy/CpxP family protein refolding chaperone	-
C2L64_RS07100	1587757..1588641	+	885	WP_090836036.1	LysR family transcriptional regulator	-
C2L64_RS07105	1588779..1589243	+	465	WP_007734062.1	Lrp/AsnC family transcriptional regulator	-
C2L64_RS07110	1589451..1590548	+	1098	WP_090836037.1	saccharopine dehydrogenase NADP-binding domain-containing protein	-
C2L64_RS07115	1590711..1591331	-	621	WP_090836038.1	ATP-binding protein	-
C2L64_RS07120	1591502..1591747	+	246	WP_007588356.1	DNA-binding protein	Antitoxin
C2L64_RS07125	1591734..1592162	+	429	WP_086916991.1	type II toxin-antitoxin system VapC family toxin	Toxin
C2L64_RS07130	1592252..1592725	+	474	WP_024162918.1	hypothetical protein	-
C2L64_RS07135	1592930..1593907	+	978	WP_007588359.1	magnesium/cobalt transporter CorA	-
C2L64_RS07140	1593959..1594597	-	639	WP_007739112.1	LysE family translocator	-
C2L64_RS07145	1595148..1596104	+	957	WP_007588361.1	sugar ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-122)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 143 a.a.
• Molecular weight: 15718.91 Da
• Isoelectric Point: 6.8808

>T93323 WP_086916991.1 NZ_CP026105:1591734-1592162 [Paraburkholderia hospita]
VYLIDTNVISEMRKSSRANPGVQAFFEAAKEGGHRLYLSVVTVGELRRGVDLIRHRGDKFQALRLEGWLDTIMNSFGSQI
LNVGTDVAQTWGHLRVPDPEHSLDKLIAATALIYNLTVVTRNVADFDGTGARVLNPFQLLDA

Nucleotide

• Length: 429 bp

>T93323 NZ_CP026105:1591734-1592162 [Paraburkholderia hospita]
GTGTATTTGATTGATACCAATGTAATCAGCGAAATGCGCAAGAGCAGTCGCGCCAATCCAGGCGTGCAGGCTTTTTTCGA
AGCGGCGAAGGAAGGCGGGCATCGCCTGTATCTGTCGGTGGTGACGGTCGGCGAACTGCGGCGCGGCGTCGACCTGATCC
GGCATCGGGGCGACAAGTTCCAGGCGTTGCGCCTGGAAGGCTGGCTCGACACGATCATGAATTCGTTCGGCAGCCAGATC
CTGAATGTCGGCACCGACGTCGCGCAGACGTGGGGCCATCTGCGCGTGCCGGATCCCGAGCACTCGCTGGACAAGCTGAT
CGCGGCGACGGCCCTGATCTACAACCTGACTGTCGTGACGCGCAACGTGGCAGACTTCGATGGCACGGGCGCACGGGTGC
TGAATCCGTTCCAGCTTCTTGACGCATGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8938.94 Da
• Isoelectric Point: 4.2208

>AT93323 WP_007588356.1 NZ_CP026105:1591502-1591747 [Paraburkholderia hospita]
MANLLVRNLDDALVQNLREQAAAHGRSVEAEHREILAQALFQPKKLSFAELLMSMPDVGDDADFERRNDVTDDSGGPGVF
D

Nucleotide

• Length: 246 bp

>AT93323 NZ_CP026105:1591502-1591747 [Paraburkholderia hospita]
ATGGCAAATCTTTTGGTCCGAAATCTGGACGATGCGTTGGTGCAGAACCTGCGTGAGCAGGCCGCGGCTCACGGGCGCAG
CGTCGAAGCAGAGCATCGGGAAATCCTGGCGCAGGCGCTCTTTCAGCCCAAGAAGCTCAGCTTCGCGGAATTGCTGATGA
GCATGCCCGACGTCGGCGACGACGCCGACTTCGAGCGCCGCAATGACGTAACTGACGATAGCGGGGGACCGGGTGTATTT
GATTGA

Structures

Antitoxin

• AlphaFold DB: A0A7Z7B428