Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1270744..1271263 Replicon chromosome
Accession NZ_CP026105
Organism Paraburkholderia hospita strain DSM 17164

Toxin (Protein)


Gene name relE Uniprot ID A0A244DDF8
Locus tag C2L64_RS05680 Protein ID WP_007585572.1
Coordinates 1270973..1271263 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A244DDI0
Locus tag C2L64_RS05675 Protein ID WP_007585570.1
Coordinates 1270744..1270986 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2L64_RS05650 1267406..1267678 - 273 WP_090835656.1 pyocin activator PrtN family protein -
C2L64_RS05660 1268129..1268572 + 444 WP_090835658.1 hypothetical protein -
C2L64_RS05665 1268572..1269183 + 612 WP_090835711.1 lipase -
C2L64_RS05670 1269493..1270524 - 1032 WP_090835661.1 IS1595 family transposase -
C2L64_RS05675 1270744..1270986 + 243 WP_007585570.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
C2L64_RS05680 1270973..1271263 + 291 WP_007585572.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C2L64_RS05685 1271371..1271991 + 621 WP_090835663.1 glutathione S-transferase -
C2L64_RS05695 1272209..1272400 + 192 WP_007585578.1 hypothetical protein -
C2L64_RS05700 1272528..1273931 + 1404 WP_090835714.1 FAD-containing oxidoreductase -
C2L64_RS05705 1273943..1274275 + 333 WP_007585581.1 cupin domain-containing protein -
C2L64_RS05710 1274417..1274992 + 576 WP_007585583.1 DUF1211 domain-containing protein -
C2L64_RS05715 1274996..1275784 + 789 WP_007585586.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1269493..1270524 1031


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(8-71)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10981.84 Da        Isoelectric Point: 10.5985

>T93322 WP_007585572.1 NZ_CP026105:1270973-1271263 [Paraburkholderia hospita]
MTIYKLQFLESAQKEWSKLDNTVRSQLKRKLAERLENPRVESARLSTMPDCYKIKLAASGYRLVYQVADRTVTVTVISVG
KRERSAVYAAAIARLM

Download         Length: 291 bp

>T93322 NZ_CP026105:1270973-1271263 [Paraburkholderia hospita]
TTGACGATCTATAAACTGCAGTTTCTTGAATCTGCCCAAAAGGAATGGAGCAAGCTCGATAACACGGTCCGTTCGCAGTT
AAAACGCAAGCTGGCCGAACGGCTGGAGAATCCGCGAGTCGAGTCGGCACGGCTGAGCACGATGCCAGACTGCTACAAAA
TCAAGCTTGCTGCATCGGGTTACAGACTGGTGTATCAGGTTGCGGACCGTACCGTGACGGTCACGGTGATTTCCGTTGGC
AAGCGCGAAAGAAGCGCAGTCTATGCTGCAGCAATTGCGCGTCTGATGTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8657.90 Da        Isoelectric Point: 4.1954

>AT93322 WP_007585570.1 NZ_CP026105:1270744-1270986 [Paraburkholderia hospita]
MESILARTSIGISELKVNPTAAIEQADGPVAVLNRNKPVAYLIPAAEWEAICERLEDIELAEIVRARSGEKAVSVNLDDL

Download         Length: 243 bp

>AT93322 NZ_CP026105:1270744-1270986 [Paraburkholderia hospita]
ATGGAAAGCATTCTTGCGCGCACTTCAATCGGCATCAGCGAGCTCAAGGTCAACCCGACGGCAGCAATTGAGCAGGCAGA
CGGTCCGGTCGCGGTGCTGAATCGAAACAAGCCGGTCGCGTACCTGATCCCTGCGGCCGAATGGGAAGCGATTTGCGAGC
GACTCGAAGATATCGAGCTGGCGGAGATCGTCAGGGCGCGAAGCGGCGAGAAAGCCGTGAGCGTAAATCTTGACGATCTA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A244DDF8

Antitoxin

Source ID Structure
AlphaFold DB A0A244DDI0

References