Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 2770281..2772031 Replicon chromosome
Accession NZ_CP026102
Organism Paraburkholderia caribensis strain DSM 13236

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag C2L66_RS28960 Protein ID WP_054933313.1
Coordinates 2771138..2772031 (-) Length 298 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag C2L66_RS28955 Protein ID WP_054933339.1
Coordinates 2770281..2771141 (-) Length 287 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2L66_RS28935 2765480..2766976 - 1497 WP_060604768.1 aldehyde dehydrogenase -
C2L66_RS28940 2767001..2767831 - 831 WP_054933316.1 aspartate dehydrogenase -
C2L66_RS28945 2767824..2769482 - 1659 WP_060604765.1 thiamine pyrophosphate-binding protein -
C2L66_RS28950 2769475..2770281 - 807 WP_060604762.1 SDR family oxidoreductase -
C2L66_RS28955 2770281..2771141 - 861 WP_054933339.1 IclR family transcriptional regulator Antitoxin
C2L66_RS28960 2771138..2772031 - 894 WP_054933313.1 alpha/beta fold hydrolase Toxin
C2L66_RS28965 2772057..2772596 - 540 WP_035999007.1 cupin domain-containing protein -
C2L66_RS28970 2772632..2773390 - 759 WP_054933312.1 SDR family oxidoreductase -
C2L66_RS28975 2773383..2774471 - 1089 WP_060604759.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
C2L66_RS28980 2774526..2774837 - 312 WP_035999001.1 hypothetical protein -
C2L66_RS28985 2774839..2775156 - 318 WP_035998998.1 non-heme iron oxygenase ferredoxin subunit -
C2L66_RS28990 2775598..2776671 + 1074 WP_060604756.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(50-276)

Antitoxin

Transcription regulator IclR, C-terminal

(144-267)


Sequences

Toxin        


Download         Length: 298 a.a.        Molecular weight: 31101.10 Da        Isoelectric Point: 6.4894

>T93321 WP_054933313.1 NZ_CP026102:c2772031-2771138 [Paraburkholderia caribensis]
MSAALPVTVDRTVTLETRLSHFPARRIAIAPQCAIGYREAGAGHADALPLVLLHGIGSGAASWVQQLDALGTTRRVFAWD
APGYGESTPVASASPKADEYAGALDAWLDALAVERCVLVGHSLGAIIAGSYAASRAQRVAGLLLISPAAGYGTASEDVRA
SKRDSRLAMLAELGPQGLADQRSANMLSPYADEASRDWVRWNMSRIVPTGYAQATHLLANADLASDVARVNGPIAVAVGA
EDSITPPSSCERIAQAARTRLQIIPRAGHAGYIEAANEYTALIDAFCRASDGQWSKA

Download         Length: 894 bp

>T93321 NZ_CP026102:c2772031-2771138 [Paraburkholderia caribensis]
ATGTCCGCAGCCTTGCCCGTCACTGTCGATCGAACCGTCACGCTGGAAACGCGCCTCTCGCACTTCCCGGCACGGCGGAT
CGCGATTGCGCCGCAATGCGCGATCGGCTATCGCGAAGCGGGTGCTGGGCACGCCGATGCGTTGCCGCTCGTGCTGTTGC
ACGGCATTGGTTCGGGCGCGGCTTCGTGGGTGCAACAACTCGACGCGTTGGGCACGACGCGCCGCGTGTTCGCTTGGGAC
GCGCCGGGCTATGGCGAATCGACGCCTGTTGCATCGGCTTCGCCCAAAGCAGATGAATATGCCGGCGCGCTCGACGCATG
GCTCGATGCGCTCGCCGTAGAACGTTGCGTACTGGTCGGCCATTCGCTCGGCGCGATCATCGCGGGCTCGTACGCGGCAT
CGCGTGCGCAACGCGTCGCGGGGCTGTTGCTGATTTCGCCCGCGGCAGGCTACGGCACGGCATCCGAAGACGTGCGCGCG
TCGAAGCGCGACAGCCGTCTCGCGATGCTCGCCGAACTCGGCCCGCAAGGTCTCGCGGACCAACGCAGCGCCAACATGCT
GTCGCCGTACGCCGATGAAGCATCACGCGACTGGGTGCGCTGGAACATGTCGCGCATCGTGCCGACGGGTTACGCGCAGG
CGACGCATCTGCTCGCCAACGCGGATCTCGCCAGCGATGTCGCGAGGGTCAACGGCCCAATCGCCGTCGCGGTCGGGGCG
GAGGACTCGATCACCCCGCCGTCGTCATGCGAGCGGATTGCACAGGCGGCGCGCACGCGCCTGCAGATCATCCCGCGCGC
GGGTCACGCGGGCTACATCGAAGCGGCCAATGAATACACCGCGCTCATCGACGCATTCTGCCGCGCGAGCGACGGTCAAT
GGAGCAAAGCATGA

Antitoxin


Download         Length: 287 a.a.        Molecular weight: 31435.86 Da        Isoelectric Point: 6.5093

>AT93321 WP_054933339.1 NZ_CP026102:c2771141-2770281 [Paraburkholderia caribensis]
MTPELTGTAPEAEDDRNDAGYRVPGLERGLRILTEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADRDRN
YRLGVAVLRLGFEYLSSLELTDLGLPLIEALRDATGLTTHIVIRDGRDVVFVAKAQSHAPVFSSVKVNVGTRLPAHATTH
GHVLMGDLSLDELRALYPEKTLERFTKHTPATVDELYERVRDDAVRGFAISESSFENGISVISAPVRNDTGRIAAVITTT
IPRPQIDAALLDGGLIDKVRGAAEQLSLRLNYRPSAESRYMKALGL

Download         Length: 861 bp

>AT93321 NZ_CP026102:c2771141-2770281 [Paraburkholderia caribensis]
ATGACCCCCGAATTGACGGGCACTGCGCCTGAAGCAGAAGACGACCGCAACGACGCGGGCTATCGCGTGCCCGGACTCGA
ACGCGGCCTGCGCATTCTCACGGAGTTCTCGCCGCGCGAACCGGTGCTCGGCGCGCCCGAATTGTCGAAGCGCCTCGGCA
TTCCGCGCACGACGGTGTTCCGTCTGCTGCAGACGCTCGAATCACTGGGCTTTCTGGAGCGCGCGGATCGCGACCGCAAC
TATCGCCTGGGCGTCGCGGTGCTGCGCCTCGGCTTCGAATATCTCAGTTCGCTCGAACTCACCGATCTCGGCTTGCCGTT
GATCGAAGCTTTGCGCGATGCAACGGGGCTGACCACGCACATCGTGATCCGCGACGGCCGCGACGTGGTGTTCGTCGCGA
AGGCGCAGAGTCATGCGCCCGTGTTCAGTTCGGTGAAGGTCAACGTCGGCACGCGGCTACCCGCGCATGCGACTACGCAC
GGTCATGTGCTGATGGGCGATCTCTCGCTCGACGAACTGCGCGCGCTGTATCCGGAGAAGACGCTCGAACGCTTCACGAA
ACACACGCCCGCTACCGTTGACGAACTATACGAGCGCGTGAGGGACGACGCGGTGCGCGGTTTCGCGATCAGCGAATCGT
CCTTCGAAAACGGTATCTCCGTCATCAGTGCGCCCGTGCGCAACGACACGGGCCGCATCGCCGCTGTCATCACCACCACC
ATTCCGCGCCCGCAGATCGACGCGGCGCTGCTCGACGGCGGCCTGATCGACAAGGTGCGCGGCGCGGCGGAGCAATTGTC
GCTGCGGCTGAACTACCGGCCGTCGGCGGAAAGCAGGTACATGAAGGCATTGGGGCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References