Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-StbC
Location 1583095..1583755 Replicon chromosome
Accession NZ_CP026101
Organism Paraburkholderia caribensis strain DSM 13236

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag C2L66_RS07045 Protein ID WP_082434037.1
Coordinates 1583327..1583755 (+) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag C2L66_RS07040 Protein ID WP_060602697.1
Coordinates 1583095..1583340 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2L66_RS07015 1578688..1579200 - 513 WP_060601139.1 Spy/CpxP family protein refolding chaperone -
C2L66_RS07020 1579353..1580237 + 885 WP_054934550.1 LysR family transcriptional regulator -
C2L66_RS07025 1580374..1580838 + 465 WP_035990996.1 Lrp/AsnC family transcriptional regulator -
C2L66_RS07030 1581046..1582143 + 1098 WP_035990998.1 saccharopine dehydrogenase NADP-binding domain-containing protein -
C2L66_RS07035 1582305..1582925 - 621 WP_060601137.1 ATP-binding protein -
C2L66_RS07040 1583095..1583340 + 246 WP_060602697.1 hypothetical protein Antitoxin
C2L66_RS07045 1583327..1583755 + 429 WP_082434037.1 type II toxin-antitoxin system VapC family toxin Toxin
C2L66_RS07050 1583844..1584317 + 474 WP_060601133.1 hypothetical protein -
C2L66_RS07055 1584522..1585499 + 978 WP_054934556.1 magnesium/cobalt transporter CorA -
C2L66_RS07060 1585542..1586180 - 639 WP_054934557.1 LysE family translocator -
C2L66_RS07065 1586731..1587687 + 957 WP_054934558.1 sugar ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15715.91 Da        Isoelectric Point: 7.4682

>T93319 WP_082434037.1 NZ_CP026101:1583327-1583755 [Paraburkholderia caribensis]
VYLIDTNVISEMRKSSRANPGVQAFFETAKEGGHRLYLSVVTVGELRRGVDLIRHRGDKFQALRLEGWLDTIMNSFSSHI
LNVGTDVAQTWGHLRVPDPGHSLDKLIAATALIYNLTVVTRNVADFDGTGARVLNPFQLLDA

Download         Length: 429 bp

>T93319 NZ_CP026101:1583327-1583755 [Paraburkholderia caribensis]
GTGTATTTGATTGATACCAATGTAATCAGCGAAATGCGCAAGAGCAGCCGCGCCAATCCGGGCGTACAGGCTTTTTTCGA
AACGGCGAAGGAAGGCGGGCATCGCCTGTATCTGTCTGTGGTGACGGTTGGCGAGTTGCGGCGCGGCGTCGACCTGATCC
GGCATCGGGGCGACAAGTTCCAGGCATTGCGCCTGGAAGGCTGGCTCGACACGATCATGAATTCGTTCAGCAGCCACATC
TTGAATGTCGGCACCGACGTTGCGCAGACGTGGGGCCATCTGCGCGTGCCCGACCCCGGGCATTCGCTGGACAAACTGAT
CGCGGCCACGGCCCTGATCTACAACCTGACTGTCGTGACGCGCAACGTGGCAGACTTCGATGGCACGGGCGCACGGGTGC
TCAATCCGTTCCAGCTTCTCGACGCATGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8910.88 Da        Isoelectric Point: 4.2208

>AT93319 WP_060602697.1 NZ_CP026101:1583095-1583340 [Paraburkholderia caribensis]
MANLLVRNLDDALVQNLREQAAAHGRSVEAEHREILAQALFQPKKLSFAELLMSMPDVGDDADFERRNDATDDSGGPGVF
D

Download         Length: 246 bp

>AT93319 NZ_CP026101:1583095-1583340 [Paraburkholderia caribensis]
ATGGCAAATCTTTTGGTCCGAAATCTGGACGATGCGTTGGTGCAGAACCTGCGTGAGCAGGCCGCGGCTCACGGGCGCAG
CGTCGAAGCAGAGCATCGGGAAATCCTGGCGCAGGCGCTCTTTCAGCCCAAGAAGCTCAGCTTTGCGGAATTGCTGATGA
GCATGCCCGACGTCGGCGACGACGCCGACTTCGAGCGCCGCAATGACGCAACTGACGATAGCGGGGGACCGGGTGTATTT
GATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References