Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2002676..2004363 Replicon chromosome
Accession NZ_CP026100
Organism Caulobacter flavus strain RHGG3

Toxin (Protein)


Gene name HipA2 Uniprot ID -
Locus tag C1707_RS09405 Protein ID WP_101713821.1
Coordinates 2002676..2004010 (-) Length 445 a.a.

Antitoxin (Protein)


Gene name HipB2 Uniprot ID -
Locus tag C1707_RS09410 Protein ID WP_101713890.1
Coordinates 2004007..2004363 (-) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1707_RS09390 1997801..1998388 + 588 WP_101713818.1 TetR/AcrR family transcriptional regulator -
C1707_RS09395 1998373..1999188 - 816 WP_101713819.1 hypothetical protein -
C1707_RS09400 1999341..2002553 + 3213 WP_101713820.1 DUF4981 domain-containing protein -
C1707_RS09405 2002676..2004010 - 1335 WP_101713821.1 HipA domain-containing protein Toxin
C1707_RS09410 2004007..2004363 - 357 WP_101713890.1 helix-turn-helix transcriptional regulator Antitoxin
C1707_RS09415 2004559..2005512 - 954 WP_101713822.1 bifunctional helix-turn-helix transcriptional regulator/GNAT family N-acetyltransferase -
C1707_RS09420 2005742..2007979 + 2238 WP_205686831.1 heparinase II/III family protein -
C1707_RS09425 2007976..2009244 + 1269 WP_101713823.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(6-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(62-112)


Sequences

Toxin        


Download         Length: 445 a.a.        Molecular weight: 48605.17 Da        Isoelectric Point: 5.2306

>T93315 WP_101713821.1 NZ_CP026100:c2004010-2002676 [Caulobacter flavus]
MSRPTQLVVHMDGVARPAGYLVSNETQAISFAYDLRYAEEGGPPLSMSMPLEQADFGDVTARAFFDNLLPENNQMQQVMD
REGLARDDVVGLLAHLGADCSGAISCLPFGAEPVKVPGVLAEDYEPIAPEALAEIVRSLAEHRRLPDTAADPSPVAGVQR
KIALVHTPAGFARPKPGRKVPTTHILKVPERRLGRDAGLEEQAARLAWAVGLKVSIPQAARIADVDALLITRFDRWERDG
VVYRIHQEDFAQALGLPATLKYQRNGEAGRRFDAEAIARVLDRTERPALARQAFLATTLFNLLIGNTDNHAKNHGLLYAS
GRAPILAPLYDLLPSRLNPDFNDQLSFDIGGADHPDAITRDDLLDFLGAFQMTRAAASRFLDRTATSMVEALEAATRDLA
SRGFKDLDDLIGRETEQLVEVLGLDVKVRERDYFPKGRYALGAS

Download         Length: 1335 bp

>T93315 NZ_CP026100:c2004010-2002676 [Caulobacter flavus]
ATGAGCCGTCCGACCCAGCTGGTCGTCCACATGGACGGCGTGGCTCGGCCCGCCGGCTATCTGGTATCGAACGAGACCCA
GGCGATCAGCTTCGCCTATGACCTGCGGTACGCCGAAGAAGGCGGCCCGCCGCTGTCGATGTCGATGCCGCTGGAGCAGG
CCGACTTCGGCGACGTGACCGCGCGGGCGTTCTTCGACAACCTGCTGCCCGAAAACAACCAGATGCAGCAGGTGATGGAC
CGCGAGGGCCTGGCGCGGGACGACGTCGTCGGCCTGCTGGCCCATCTGGGCGCCGACTGCTCGGGGGCGATCTCCTGCCT
GCCGTTCGGCGCCGAGCCGGTGAAGGTTCCGGGCGTGCTGGCCGAGGACTACGAGCCGATCGCGCCCGAGGCGCTGGCCG
AGATCGTTCGCAGCCTGGCCGAGCACCGGCGCCTGCCCGACACGGCGGCCGACCCGTCGCCGGTCGCCGGCGTCCAGCGC
AAGATCGCCCTGGTCCACACCCCTGCCGGCTTCGCCCGGCCCAAGCCGGGGCGCAAGGTTCCGACGACGCACATATTGAA
GGTTCCCGAGCGCCGCCTGGGCCGCGACGCGGGCCTGGAGGAGCAGGCGGCGAGGCTGGCCTGGGCGGTCGGCCTGAAGG
TCTCGATCCCGCAAGCCGCCCGCATCGCCGACGTCGACGCCCTGCTGATCACCCGCTTCGACCGTTGGGAGCGGGACGGC
GTCGTCTATCGCATCCACCAGGAGGACTTCGCCCAGGCCCTGGGCCTGCCCGCGACCCTGAAGTACCAGCGCAACGGCGA
GGCGGGCCGCCGGTTCGACGCCGAGGCGATCGCTCGCGTGCTGGACCGGACCGAGCGCCCGGCCCTGGCGCGCCAGGCGT
TCCTGGCGACGACGCTGTTCAACCTGCTGATCGGCAACACCGACAACCACGCCAAGAACCACGGCCTGCTCTACGCCTCG
GGCCGCGCCCCGATCCTGGCGCCGCTGTACGACCTGCTGCCCAGCCGCCTGAACCCGGACTTCAACGACCAGCTGTCGTT
CGACATCGGCGGCGCCGACCACCCCGACGCGATCACCCGCGACGATCTCCTCGACTTCCTGGGCGCCTTCCAGATGACGA
GGGCGGCCGCGTCGCGCTTCCTCGATCGAACCGCCACGTCCATGGTCGAGGCGCTGGAAGCCGCGACGCGGGACCTGGCG
AGCCGGGGTTTCAAGGACCTGGACGACTTGATCGGCCGCGAGACCGAGCAGTTGGTCGAGGTCTTGGGCCTCGATGTGAA
GGTGCGCGAACGCGACTACTTCCCCAAGGGACGCTACGCCCTCGGAGCCAGCTAG

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 12342.29 Da        Isoelectric Point: 10.7180

>AT93315 WP_101713890.1 NZ_CP026100:c2004363-2004007 [Caulobacter flavus]
MSKVIERISARDLARAIATGGIKINRMTPPAAPARDQDPAGPAPSPRPATHVGTPAELGRLIRQAREAMDLTQAQFADMA
GVGRRFVSELENGKATLELGKVMAACAAAGLDLLAVTR

Download         Length: 357 bp

>AT93315 NZ_CP026100:c2004363-2004007 [Caulobacter flavus]
ATGAGCAAGGTGATCGAGCGCATATCGGCGCGCGATCTCGCCCGCGCCATCGCCACTGGCGGCATAAAGATCAACCGTAT
GACGCCGCCGGCCGCCCCGGCGCGCGACCAGGATCCCGCCGGCCCCGCCCCATCGCCGCGTCCGGCCACGCACGTTGGCA
CGCCCGCTGAGCTCGGCCGCCTGATCCGCCAGGCCCGCGAGGCCATGGACCTGACCCAGGCGCAGTTCGCCGACATGGCC
GGGGTCGGGCGCCGGTTCGTGTCCGAACTGGAGAACGGCAAGGCGACCCTGGAGCTGGGCAAGGTGATGGCCGCCTGCGC
CGCCGCCGGTCTCGACCTGCTGGCGGTCACGCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References