Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | itaRT/DUF1778(antitoxin) |
| Location | 3905923..3906760 | Replicon | chromosome |
| Accession | NZ_CP026098 | ||
| Organism | Shigella flexneri strain FDAARGOS_74 | ||
Toxin (Protein)
| Gene name | itaT | Uniprot ID | - |
| Locus tag | MC63_RS20210 | Protein ID | WP_025758752.1 |
| Coordinates | 3905923..3906465 (-) | Length | 181 a.a. |
Antitoxin (Protein)
| Gene name | itaR | Uniprot ID | A0A658YW11 |
| Locus tag | MC63_RS20215 | Protein ID | WP_005072928.1 |
| Coordinates | 3906449..3906760 (-) | Length | 104 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MC63_RS20190 (3901653) | 3901653..3903023 | - | 1371 | WP_001000943.1 | MFS transporter | - |
| MC63_RS20195 (3903390) | 3903390..3904691 | + | 1302 | WP_252988323.1 | tetratricopeptide repeat protein | - |
| MC63_RS20200 (3904688) | 3904688..3904921 | + | 234 | WP_134800446.1 | hypothetical protein | - |
| MC63_RS20205 (3904932) | 3904932..3905867 | + | 936 | WP_024259953.1 | tetratricopeptide repeat protein | - |
| MC63_RS20210 (3905923) | 3905923..3906465 | - | 543 | WP_025758752.1 | GNAT family N-acetyltransferase | Toxin |
| MC63_RS20215 (3906449) | 3906449..3906760 | - | 312 | WP_005072928.1 | DUF1778 domain-containing protein | Antitoxin |
| MC63_RS20220 (3906945) | 3906945..3907835 | - | 891 | WP_025758754.1 | heme o synthase | - |
| MC63_RS20225 (3907847) | 3907847..3908176 | - | 330 | WP_000019869.1 | cytochrome o ubiquinol oxidase subunit IV | - |
| MC63_RS20230 (3908176) | 3908176..3908790 | - | 615 | WP_000179819.1 | cytochrome o ubiquinol oxidase subunit III | - |
| MC63_RS20235 (3908780) | 3908780..3909010 | - | 231 | WP_032327101.1 | hypothetical protein | - |
| MC63_RS20240 (3909016) | 3909016..3909690 | + | 675 | WP_001088287.1 | IS66-like element accessory protein TnpA | - |
| MC63_RS20245 (3909687) | 3909687..3910034 | + | 348 | WP_000631709.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| MC63_RS20250 (3910054) | 3910054..3911655 | + | 1602 | WP_040235286.1 | IS66-like element ISSfl3 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 181 a.a. Molecular weight: 19835.99 Da Isoelectric Point: 8.6178
>T93307 WP_025758752.1 NZ_CP026098:c3906465-3905923 [Shigella flexneri]
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLER
QRVSGVLQGSQPSEIGVVRLVMLGGARKYQKRGFGQDLLCDFFEHVKKIHQALPIKGVYLDADPATINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLER
QRVSGVLQGSQPSEIGVVRLVMLGGARKYQKRGFGQDLLCDFFEHVKKIHQALPIKGVYLDADPATINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA
Download Length: 543 bp
>T93307 NZ_CP026098:c3906465-3905923 [Shigella flexneri]
ATGGTCGACAAGCATGAAGAGATTACTCTGCCCATAGTCCTCTCCTGTAATTATCAGTCTGATATTACTTATCCTGGGCA
AAAACAGTTTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACT
GTGCGGCTAAAGCACTTATTGACAGACAAAGTGGTGAACTGATTGGCATCTGTACTTTTACGGCATATTCGCTGGAAAGA
CAACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAAATTGGTGTTGTCAGATTAGTCATGTTGGGGGGAGCGCG
GAAGTATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTGATTTTTTTGAACATGTAAAAAAAATTCACCAGGCATTAC
CAATTAAAGGGGTTTATCTTGATGCTGACCCTGCCACCATTAACTTTTATGCTCGTCTCGGCTTTGTTCAGCTTTCAGCG
ACACCAAATGCTTTTGGTGCTGTACCTATGTTTTTGGCGATTCAGCATATTCTCGCGGCTTAG
ATGGTCGACAAGCATGAAGAGATTACTCTGCCCATAGTCCTCTCCTGTAATTATCAGTCTGATATTACTTATCCTGGGCA
AAAACAGTTTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACT
GTGCGGCTAAAGCACTTATTGACAGACAAAGTGGTGAACTGATTGGCATCTGTACTTTTACGGCATATTCGCTGGAAAGA
CAACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAAATTGGTGTTGTCAGATTAGTCATGTTGGGGGGAGCGCG
GAAGTATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTGATTTTTTTGAACATGTAAAAAAAATTCACCAGGCATTAC
CAATTAAAGGGGTTTATCTTGATGCTGACCCTGCCACCATTAACTTTTATGCTCGTCTCGGCTTTGTTCAGCTTTCAGCG
ACACCAAATGCTTTTGGTGCTGTACCTATGTTTTTGGCGATTCAGCATATTCTCGCGGCTTAG
Antitoxin
Download Length: 104 a.a. Molecular weight: 11410.11 Da Isoelectric Point: 10.3388
>AT93307 WP_005072928.1 NZ_CP026098:c3906760-3906449 [Shigella flexneri]
MLGKTAALYDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA
MLGKTAALYDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA
Download Length: 312 bp
>AT93307 NZ_CP026098:c3906760-3906449 [Shigella flexneri]
ATGCTTGGAAAAACAGCCGCTCTATACGATGTCGATAAAACGCTGAAAAATGCGCGGGTCGAACTCAAAACTAGTCCCGA
CGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCTGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA
ATGCTTGGAAAAACAGCCGCTCTATACGATGTCGATAAAACGCTGAAAAATGCGCGGGTCGAACTCAAAACTAGTCCCGA
CGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCTGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|