Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2677598..2678124 | Replicon | chromosome |
| Accession | NZ_CP026098 | ||
| Organism | Shigella flexneri strain FDAARGOS_74 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | MC63_RS13730 | Protein ID | WP_000323025.1 |
| Coordinates | 2677598..2677885 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | MC63_RS13735 | Protein ID | WP_000534858.1 |
| Coordinates | 2677885..2678124 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MC63_RS13675 (2672658) | 2672658..2672993 | + | 336 | WP_000871291.1 | anti-adapter protein IraM | - |
| MC63_RS13680 (2673274) | 2673274..2673360 | - | 87 | WP_000115835.1 | DUF3927 family protein | - |
| MC63_RS13685 (2673441) | 2673441..2673719 | - | 279 | WP_001017786.1 | hypothetical protein | - |
| MC63_RS13700 (2674302) | 2674302..2675123 | - | 822 | WP_000762884.1 | antitermination protein | - |
| MC63_RS13705 (2675138) | 2675138..2675494 | - | 357 | WP_000904111.1 | RusA family crossover junction endodeoxyribonuclease | - |
| MC63_RS13710 (2675507) | 2675507..2676556 | - | 1050 | WP_025759563.1 | DUF968 domain-containing protein | - |
| MC63_RS13715 (2676558) | 2676558..2676836 | - | 279 | WP_024258459.1 | hypothetical protein | - |
| MC63_RS13720 (2676903) | 2676903..2677153 | - | 251 | Protein_2618 | hypothetical protein | - |
| MC63_RS13725 (2677371) | 2677371..2677526 | - | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| MC63_RS13730 (2677598) | 2677598..2677885 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| MC63_RS13735 (2677885) | 2677885..2678124 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| MC63_RS13740 (2678149) | 2678149..2678454 | + | 306 | WP_071818640.1 | hypothetical protein | - |
| MC63_RS25285 (2679671) | 2679671..2680029 | + | 359 | Protein_2624 | type 1 fimbrial protein | - |
| MC63_RS13760 (2680042) | 2680042..2680407 | + | 366 | Protein_2625 | type 1 fimbrial protein | - |
| MC63_RS13765 (2680558) | 2680558..2680923 | + | 366 | Protein_2626 | type 1 fimbrial protein | - |
| MC63_RS13770 (2680998) | 2680998..2681207 | - | 210 | Protein_2627 | IS1 family transposase | - |
| MC63_RS25730 (2682477) | 2682477..2683028 | - | 552 | Protein_2629 | IS1 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2655005..2682834 | 27829 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T93304 WP_000323025.1 NZ_CP026098:c2677885-2677598 [Shigella flexneri]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T93304 NZ_CP026098:c2677885-2677598 [Shigella flexneri]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT93304 WP_000534858.1 NZ_CP026098:c2678124-2677885 [Shigella flexneri]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT93304 NZ_CP026098:c2678124-2677885 [Shigella flexneri]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|