Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 518381..519012 Replicon chromosome
Accession NZ_CP026098
Organism Shigella flexneri strain FDAARGOS_74

Toxin (Protein)


Gene name hicA Uniprot ID U9Y2A7
Locus tag MC63_RS02475 Protein ID WP_001259385.1
Coordinates 518381..518656 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag MC63_RS02480 Protein ID WP_000593555.1
Coordinates 518653..519012 (+) Length 120 a.a.

Genomic Context

MC63_RS02460MC63_RS02465MC63_RS02470MC63_RS02475MC63_RS02480MC63_RS02485MC63_RS02490MC63_RS02495MC63_RS02500MC63_RS02505
Location: 513399..514466 (1068 bp)
Type: Others
Protein ID: WP_000361474.1
Location: 514463..517198 (2736 bp)
Type: Others
Protein ID: WP_025758458.1
Location: 517198..518322 (1125 bp)
Type: Others
Protein ID: WP_001216257.1
Location: 518381..518656 (276 bp)
Type: Toxin
Protein ID: WP_001259385.1
Location: 518653..519012 (360 bp)
Type: Antitoxin
Protein ID: WP_000593555.1
Location: 519132..519533 (402 bp)
Type: Others
Protein ID: WP_001190062.1
Location: 519539..520345 (807 bp)
Type: Others
Protein ID: WP_000173672.1
Location: 520342..521106 (765 bp)
Type: Others
Protein ID: WP_001136248.1
Location: 521106..521939 (834 bp)
Type: Others
Protein ID: WP_001008949.1
Location: 521936..522880 (945 bp)
Type: Others
Protein ID: WP_025758457.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
MC63_RS02460 (513399)513399..514466+1068WP_000361474.1HlyD family secretion protein-
MC63_RS02465 (514463)514463..517198+2736WP_025758458.1ribosome-associated ATPase/putative transporter RbbA-
MC63_RS02470 (517198)517198..518322+1125WP_001216257.1ABC transporter permease-
MC63_RS02475 (518381)518381..518656+276WP_001259385.1type II toxin-antitoxin system HicA family toxinToxin
MC63_RS02480 (518653)518653..519012+360WP_000593555.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
MC63_RS02485 (519132)519132..519533-402WP_001190062.1nickel-responsive transcriptional regulator NikR-
MC63_RS02490 (519539)519539..520345-807WP_000173672.1nickel import ATP-binding protein NikE-
MC63_RS02495 (520342)520342..521106-765WP_001136248.1nickel import ATP-binding protein NikD-
MC63_RS02500 (521106)521106..521939-834WP_001008949.1nickel ABC transporter permease subunit NikC-
MC63_RS02505 (521936)521936..522880-945WP_025758457.1nickel ABC transporter permease subunit NikB-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10199.94 Da        Isoelectric Point: 10.7076

>T93288 WP_001259385.1 NZ_CP026098:518381-518656 [Shigella flexneri]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

>T93288 NZ_CP026098:518381-518656 [Shigella flexneri]
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAAACACCTGTTCCTCAAGG
GATCAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGCAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT93288 WP_000593555.1 NZ_CP026098:518653-519012 [Shigella flexneri]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp

>AT93288 NZ_CP026098:518653-519012 [Shigella flexneri]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCAGCTGTTATTACCTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGTATTCAGGGGCTGCAAAAAGAAGGAG
AGCTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACATTGAATGAGCGTTTGAATCATTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A4P7TTW8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A7U9LKZ6

References