Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higB-toxA/Tad-HTH_37
Location 417172..417800 Replicon chromosome
Accession NZ_CP026097
Organism Lacticaseibacillus paracasei strain HDS-01

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag C1191_RS02125 Protein ID WP_003583266.1
Coordinates 417432..417800 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name toxA Uniprot ID -
Locus tag C1191_RS02120 Protein ID WP_003583264.1
Coordinates 417172..417432 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1191_RS02095 413063..413806 + 744 WP_003563368.1 SDR family oxidoreductase -
C1191_RS02100 413919..414545 + 627 WP_003583257.1 flavodoxin -
C1191_RS02105 414796..415299 + 504 WP_003583259.1 TetR/AcrR family transcriptional regulator -
C1191_RS02110 415304..416365 + 1062 WP_003583262.1 ABC transporter permease -
C1191_RS02115 416370..417059 + 690 WP_003583263.1 ABC transporter ATP-binding protein -
C1191_RS02120 417172..417432 - 261 WP_003583264.1 helix-turn-helix transcriptional regulator Antitoxin
C1191_RS02125 417432..417800 - 369 WP_003583266.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C1191_RS02130 418091..419461 - 1371 WP_003573580.1 FAD-dependent oxidoreductase -
C1191_RS02135 419825..420643 - 819 WP_101512325.1 Cof-type HAD-IIB family hydrolase -
C1191_RS02140 420963..421232 - 270 WP_003563382.1 type II toxin-antitoxin system YafQ family toxin -
C1191_RS02145 421473..422480 + 1008 WP_003563383.1 LacI family DNA-binding transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(34-112)

Antitoxin

Cro/C1-type helix-turn-helix domain

(28-79)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 14939.01 Da        Isoelectric Point: 8.3986

>T93285 WP_003583266.1 NZ_CP026097:c417800-417432 [Lacticaseibacillus paracasei]
MYKIDFYEDRDGYSEIEDFLDQLRHSHQKNNVSLLNKITKELYMLQNLGPRLREPHAKFLKGYAYPIMELRPMPERIFYA
AWQKDHFVLLHHYTKKTNKTDHREILRAQSNLEDWLSRKEEN

Download         Length: 369 bp

>T93285 NZ_CP026097:c417800-417432 [Lacticaseibacillus paracasei]
ATGTATAAAATTGACTTCTATGAGGATCGCGATGGCTACTCTGAGATCGAAGACTTTCTTGATCAGTTACGCCATAGTCA
TCAAAAAAATAATGTGAGCCTTTTAAACAAAATCACAAAGGAACTCTACATGCTGCAAAATCTTGGTCCGCGCTTACGTG
AACCTCACGCGAAGTTTCTGAAGGGATATGCTTATCCGATCATGGAATTGCGTCCCATGCCAGAAAGAATCTTTTATGCT
GCATGGCAAAAGGATCATTTCGTTTTGCTTCATCACTACACCAAGAAAACAAACAAAACTGATCACAGAGAAATTTTACG
GGCACAGTCTAACCTCGAAGATTGGCTCTCTAGAAAGGAAGAAAATTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9828.45 Da        Isoelectric Point: 10.2439

>AT93285 WP_003583264.1 NZ_CP026097:c417432-417172 [Lacticaseibacillus paracasei]
MTTWEDFSQKLKKDNPEKLAIIKTLADLESERIKQGISQKDFAEKIGMKQPQLAKIERLDSLPTLATLNRYARGLGKEIR
LSIVTQ

Download         Length: 261 bp

>AT93285 NZ_CP026097:c417432-417172 [Lacticaseibacillus paracasei]
ATGACGACATGGGAAGACTTCAGTCAGAAACTGAAGAAGGACAATCCAGAAAAGTTGGCAATCATCAAAACCTTGGCCGA
TTTAGAAAGTGAACGAATCAAGCAAGGAATCTCTCAAAAGGACTTTGCAGAAAAAATTGGTATGAAACAGCCGCAACTAG
CAAAGATTGAGCGCTTAGACTCTCTTCCGACTCTGGCAACACTCAATCGATACGCGAGAGGGCTTGGAAAAGAAATTCGT
TTATCAATTGTTACTCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References