Detailed information of TA system TA093283

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2776269..2776948
• Replicon: chromosome
• Accession: NZ_CP026089
• Organism: Acinetobacter pittii strain WCHAP005069

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: C2U64_RS14755
• Protein ID: WP_000838146.1
• Coordinates: 2776766..2776948 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: C2U64_RS14750
• Protein ID: WP_000966688.1
• Coordinates: 2776269..2776673 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C2U64_RS14740	2775225..2775488	-	264	WP_001275792.1	hypothetical protein	-
C2U64_RS14745	2775490..2776170	-	681	WP_000721572.1	hypothetical protein	-
C2U64_RS14750	2776269..2776673	-	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
C2U64_RS14755	2776766..2776948	-	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
C2U64_RS14760	2777274..2777789	-	516	WP_025464105.1	hypothetical protein	-
C2U64_RS14765	2777860..2778777	-	918	WP_002121543.1	hypothetical protein	-
C2U64_RS14770	2778830..2780158	-	1329	WP_023187966.1	hypothetical protein	-
C2U64_RS14775	2780158..2780511	-	354	WP_002121621.1	hypothetical protein	-
C2U64_RS14780	2780580..2780978	-	399	WP_002121567.1	hypothetical protein	-
C2U64_RS14785	2780980..2781348	-	369	WP_000539743.1	hypothetical protein	-
C2U64_RS14790	2781320..2781724	-	405	WP_002121581.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2750674..2800660	49986

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T93283 WP_000838146.1 NZ_CP026089:c2776948-2776766 [Acinetobacter pittii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T93283 NZ_CP026089:c2776948-2776766 [Acinetobacter pittii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT93283 WP_000966688.1 NZ_CP026089:c2776673-2776269 [Acinetobacter pittii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT93283 NZ_CP026089:c2776673-2776269 [Acinetobacter pittii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6