Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 95125..95653 Replicon plasmid pOXA58_005069
Accession NZ_CP026086
Organism Acinetobacter pittii strain WCHAP005069

Toxin (Protein)


Gene name relE Uniprot ID N9N871
Locus tag C2U64_RS00570 Protein ID WP_000221358.1
Coordinates 95125..95418 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID N9NWT9
Locus tag C2U64_RS00575 Protein ID WP_000246755.1
Coordinates 95408..95653 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2U64_RS00540 90710..91315 - 606 WP_000447788.1 LysE family translocator -
C2U64_RS00545 91365..92192 - 828 WP_000073658.1 AraC family transcriptional regulator -
C2U64_RS00550 92320..93072 - 753 Protein_97 IS1-like element ISAba3 family transposase -
C2U64_RS00555 93163..94005 - 843 WP_002002480.1 carbapenem-hydrolyzing class D beta-lactamase OXA-58 -
C2U64_RS00560 94209..94913 + 705 WP_001067858.1 IS6-like element IS26 family transposase -
C2U64_RS00570 95125..95418 - 294 WP_000221358.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C2U64_RS00575 95408..95653 - 246 WP_000246755.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
C2U64_RS00580 95850..97199 - 1350 WP_001060713.1 chromate efflux transporter -
C2U64_RS00585 97196..98122 - 927 WP_026055779.1 chromate resistance protein -
C2U64_RS00590 98237..98803 - 567 WP_000678311.1 recombinase family protein -
C2U64_RS00595 99482..99834 - 353 Protein_105 hypothetical protein -
C2U64_RS00600 100277..100564 - 288 WP_000908082.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aac(3)-IId / sul2 / aph(3'')-Ib / aph(6)-Id / aph(3')-VIa / mph(E) / msr(E) / blaOXA-58 - 1..112436 112436
- inside IScluster/Tn mph(E) / msr(E) / blaOXA-58 - 76888..94913 18025


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-84)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-72)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11292.52 Da        Isoelectric Point: 10.4753

>T93278 WP_000221358.1 NZ_CP026086:c95418-95125 [Acinetobacter pittii]
MTYKLLRHKDFTAEWEKLPVAIRDQFKKKLAKVIEQPHIPKNMLRGDLAGCYKIKLLKAGVRLVYQVKDDQVVILLITVG
KRADSIVYDEAKKRIKD

Download         Length: 294 bp

>T93278 NZ_CP026086:c95418-95125 [Acinetobacter pittii]
ATGACTTATAAGCTTTTACGTCACAAGGACTTTACAGCAGAATGGGAAAAACTCCCTGTTGCTATACGAGATCAATTTAA
AAAGAAACTAGCCAAAGTCATAGAGCAGCCACATATTCCAAAGAATATGCTTAGAGGCGATCTTGCAGGTTGCTATAAAA
TCAAATTATTAAAAGCTGGTGTCCGACTTGTCTATCAAGTTAAAGATGATCAGGTAGTTATCCTGCTCATTACCGTCGGA
AAACGAGCTGATAGCATAGTTTATGACGAAGCGAAAAAGCGAATTAAAGACTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9249.64 Da        Isoelectric Point: 4.3142

>AT93278 WP_000246755.1 NZ_CP026086:c95653-95408 [Acinetobacter pittii]
MATVNFRIDEALKEKSYSILKEQGIAPTDFFTSILEYVATTGKLPVKKALLSEEDEELLALVRKRINDPKEMFEEVTLDD
L

Download         Length: 246 bp

>AT93278 NZ_CP026086:c95653-95408 [Acinetobacter pittii]
ATGGCTACTGTTAACTTCAGGATCGATGAAGCCCTTAAAGAAAAATCTTATTCAATCCTTAAAGAGCAAGGTATTGCACC
TACTGATTTCTTCACTAGTATTCTTGAGTATGTTGCTACGACTGGGAAACTGCCTGTCAAAAAAGCTTTGCTTTCGGAAG
AAGATGAAGAATTATTAGCTCTTGTCCGTAAGCGCATTAATGATCCTAAAGAGATGTTTGAGGAAGTCACATTAGATGAC
TTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6A1RKP4

Antitoxin

Source ID Structure
AlphaFold DB A0A6A1RJ80

References