Detailed information of TA system TA093246

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): omega-epsilon-zeta/zeta-couple_hipB
• Location: 1343667..1344937
• Replicon: chromosome
• Accession: NZ_CP026084
• Organism: Streptococcus agalactiae strain NJ1606

Toxin (Protein)

• Gene name: sezT
• Uniprot ID: -
• Locus tag: C2E56_RS07000
• Protein ID: WP_161508522.1
• Coordinates: 1343667..1344461 (-)
• Length: 265 a.a.

Antitoxin (Protein)

• Gene name: sezA
• Uniprot ID: -
• Locus tag: C2E56_RS07005
• Protein ID: WP_000578719.1
• Coordinates: 1344461..1344937 (-)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C2E56_RS06990	1339995..1342067	-	2073	WP_069987943.1	AAA family ATPase	-
C2E56_RS06995	1342371..1343601	+	1231	Protein_1325	IS110 family transposase	-
C2E56_RS07000	1343667..1344461	-	795	WP_161508522.1	zeta toxin family protein	Toxin
C2E56_RS07005	1344461..1344937	-	477	WP_000578719.1	helix-turn-helix domain-containing protein	Antitoxin
C2E56_RS07010	1345007..1345297	-	291	WP_000667951.1	hypothetical protein	-
C2E56_RS07015	1345347..1345736	-	390	WP_000048066.1	hypothetical protein	-
C2E56_RS07020	1345733..1345960	-	228	WP_000110922.1	hypothetical protein	-
C2E56_RS07025	1345988..1347088	-	1101	WP_161508523.1	toprim domain-containing protein	-
C2E56_RS07030	1347128..1347766	-	639	WP_017648285.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1343667..1352721	9054

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (28-215)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 265 a.a.
• Molecular weight: 30296.21 Da
• Isoelectric Point: 5.7626

>T93246 WP_161508522.1 NZ_CP026084:c1344461-1343667 [Streptococcus agalactiae]
MRLEEFSEAEFQKALQRTIRALTRGKTIPDQPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEQLVDELSTQGYHLLIEGTLRTTQVPRQTAQLLSSKGYQISLAVIGTKPELSYLSTLIRYEE
LYAIDPNQARATPKEHHDGIVENLVDNLRELEREQLFDCIQIYQRDRTCIYNSETDEGSAAEVLQECLFGKWSKVEEEMM
KAGQERLRELCNRDREEKFEKNKS

Nucleotide

• Length: 795 bp

>T93246 NZ_CP026084:c1344461-1343667 [Streptococcus agalactiae]
ATGAGACTGGAAGAATTTAGTGAGGCTGAGTTTCAGAAGGCCTTGCAGCGAACCATTCGGGCCTTAACCCGAGGAAAGAC
GATTCCAGATCAACCGAAAGCTATCTTGCTTGGTGGACAAAGCGGAGCAGGTAAGACGACTATTCATCGTATCAAGCAAA
AGGAATTTCAAGGTAATATCATTATTATCGATGGTGACAGCTACCGTTCTCAGCATCCCAATTACTTAGCCCTGCAAGAA
AAGTATGGCAAGGATAGCGTGGACTATACCAAGGGATTTGCAGGAAAAATGGTAGAACAGTTGGTTGATGAACTCAGTAC
GCAAGGCTACCATTTGCTGATTGAGGGAACCTTGCGAACTACTCAAGTTCCTCGTCAGACTGCTCAATTATTATCTTCTA
AAGGATATCAGATTTCCTTAGCTGTGATTGGTACCAAACCAGAATTGTCCTATCTCAGCACTCTGATTCGTTATGAAGAG
CTTTATGCCATAGATCCCAATCAGGCTAGAGCAACACCAAAAGAACACCATGATGGGATTGTAGAGAACTTGGTTGATAA
CCTAAGGGAGTTAGAAAGAGAGCAACTCTTTGATTGTATTCAGATTTATCAAAGGGATAGGACTTGTATCTATAATTCTG
AAACAGATGAAGGTTCCGCAGCAGAAGTGCTACAAGAGTGTCTCTTTGGAAAATGGAGTAAAGTCGAGGAAGAGATGATG
AAGGCAGGACAGGAACGGTTGAGGGAGTTGTGTAATAGAGATAGAGAGGAAAAGTTTGAAAAAAATAAAAGCTAA

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18266.77 Da
• Isoelectric Point: 4.6424

>AT93246 WP_000578719.1 NZ_CP026084:c1344937-1344461 [Streptococcus agalactiae]
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYHLTLKVE
VIKERGAAILSKLYRYQDSQDIVFDDESNPWILMSDDLAELINTKIYLVATFDEIERYNGYLDGIERMLDMVHHRVVA

Nucleotide

• Length: 477 bp

>AT93246 NZ_CP026084:c1344937-1344461 [Streptococcus agalactiae]
ATGATCGGAGACAATATAAAATCACTACGCCGAACACACGATTTAACACAGCCAGAATTTGCGAAAATGGTTGGGATTTC
ACGCAATAGCCTGAGTCGCTACGAAAATGGTACCAGCACTGTTTCAACTGAACTCATCGACCGTATTTGTCAGAAATTTA
ACGTTTCTTATGTCGATATTGTAGGAGAGGACAAGATGTTAACACCTGTCGAAGATTACCATCTGACTTTAAAAGTAGAA
GTGATAAAAGAACGTGGAGCAGCCATTTTATCAAAGCTTTATAGATACCAGGATAGTCAAGATATTGTTTTTGATGATGA
ATCTAATCCTTGGATTTTGATGAGTGATGACTTGGCCGAATTGATCAATACGAAAATTTACCTTGTCGCTACTTTCGATG
AAATAGAGCGTTACAATGGCTATTTAGATGGTATAGAGCGGATGTTAGACATGGTGCATCATCGGGTGGTGGCTTAA