93244

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) abiEi-abiEii/AbiEii-AbiEi
Location 1371718..1373150 Replicon chromosome
Accession NZ_CP026082
Organism Streptococcus agalactiae strain YZ1605

Toxin (Protein)


Gene name abiEi Uniprot ID A0A829IAV6
Locus tag C2E46_RS06965 Protein ID WP_001030309.1
Coordinates 1372305..1373150 (+) Length 282 a.a.

Antitoxin (Protein)


Gene name abiEii Uniprot ID A0A829IE45
Locus tag C2E46_RS06960 Protein ID WP_000037244.1
Coordinates 1371718..1372308 (+) Length 197 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2E46_RS06960 1371718..1372308 + 591 WP_000037244.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
C2E46_RS06965 1372305..1373150 + 846 WP_001030309.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
C2E46_RS06970 1373212..1376013 - 2802 WP_000656706.1 CHAP domain-containing protein -
C2E46_RS06975 1376015..1376977 - 963 WP_000892893.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - wbtL 1294156..1408601 114445


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(33-258)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(6-50)


Sequences

Toxin        


Download         Length: 282 a.a.        Molecular weight: 32504.22 Da        Isoelectric Point: 5.7639

>T93244 WP_001030309.1 NZ_CP026082:1372305-1373150 [Streptococcus agalactiae]
MNKAKLTALCHKISKNTGLTFNSVMTYYFLEVILKKLSQSTYSNHYIFKGGFLLSNVIGVESRSTVDIDFLFHRITLSEE
TVKQQLKEILADSEEGISFVIQSITAIKESDDYGGYRATISCQLENIKQVIHLDIATGDVVTPQPITYDYKAIFDEDNFP
IIAYTIETILAEKLQTIYSRNFLNSRSKDFYDVYILSKLKKEDIDFIQLRNACQRTFSYRETELDFVKIIELLERFKSDP
IQNKQWQNYSKKYSYTKGISLADVLDEMIRLITVLISINSD

Download         Length: 846 bp

>T93244 NZ_CP026082:1372305-1373150 [Streptococcus agalactiae]
ATGAATAAAGCTAAGCTAACAGCACTCTGTCATAAAATATCAAAGAATACTGGATTAACCTTTAATTCCGTGATGACCTA
TTACTTTCTTGAAGTAATTTTGAAAAAATTAAGTCAGAGTACCTATTCAAATCACTATATCTTCAAAGGAGGATTCCTAC
TGTCAAATGTTATCGGAGTTGAATCTCGTAGCACGGTTGATATTGATTTTTTGTTCCATCGAATAACACTTTCAGAAGAA
ACTGTTAAACAGCAACTCAAGGAGATTTTAGCAGATTCCGAAGAGGGTATATCTTTTGTGATTCAATCAATCACAGCTAT
TAAAGAAAGTGATGACTATGGTGGCTATCGAGCAACAATTTCGTGCCAACTTGAGAATATTAAACAAGTTATCCATTTGG
ATATTGCGACAGGTGATGTTGTAACTCCTCAGCCGATTACATACGACTATAAAGCTATTTTTGATGAAGACAATTTTCCA
ATCATTGCTTATACAATTGAAACAATTCTAGCTGAAAAACTTCAAACCATCTATTCACGTAACTTCTTGAACAGTAGAAG
CAAAGATTTTTACGATGTTTATATTCTTTCAAAACTGAAGAAAGAAGACATTGACTTCATTCAGTTGAGAAATGCCTGTC
AGAGAACATTTTCATATCGCGAAACAGAACTCGATTTTGTAAAGATTATTGAACTACTCGAGAGGTTCAAATCTGACCCT
ATTCAGAATAAACAATGGCAAAATTATTCAAAAAAATATAGCTATACAAAAGGGATTTCACTTGCAGATGTTCTTGATGA
GATGATTCGTCTCATAACAGTTCTCATTTCTATAAATTCTGATTAA

Antitoxin


Download         Length: 197 a.a.        Molecular weight: 23221.78 Da        Isoelectric Point: 7.3114

>AT93244 WP_000037244.1 NZ_CP026082:1371718-1372308 [Streptococcus agalactiae]
MSKKEILLEFIENHNGIITYKDCKALNIPTIYLTRLEKEGIIYRIEKGIFLTQNGDYDEYYFFQYRFPKAIFSYISALYL
QQFTDEIPQYFDVTIPRGYRFNTPPANLNIHSVSKEYSDLGITLVKTPMGNEVKVYDLERIICDFVIHREKIDTELFVKT
LQHYGNYSKKNLTKLYEYATKMNTLDKVKQTLEVLV

Download         Length: 591 bp

>AT93244 NZ_CP026082:1371718-1372308 [Streptococcus agalactiae]
ATGTCAAAAAAAGAGATTCTACTTGAATTTATAGAAAACCACAATGGAATTATCACCTATAAAGATTGTAAAGCTCTAAA
TATTCCAACAATATATTTGACAAGACTAGAAAAAGAAGGGATTATTTACCGCATCGAAAAAGGAATTTTCCTAACCCAGA
ATGGAGACTACGATGAATACTACTTCTTTCAGTACCGTTTTCCTAAGGCTATTTTCTCTTATATCTCAGCGCTTTACCTG
CAACAATTTACAGATGAAATTCCTCAATATTTTGACGTAACCATTCCTAGAGGCTACCGTTTTAATACTCCTCCAGCAAA
TCTGAACATTCATTCCGTTTCTAAGGAATATAGCGATCTAGGAATTACACTTGTAAAAACCCCTATGGGAAACGAGGTAA
AAGTGTATGATTTAGAACGTATTATCTGTGATTTTGTGATTCATCGAGAGAAAATAGATACTGAGCTTTTTGTCAAAACG
CTTCAACATTACGGAAACTATTCTAAAAAAAATCTTACAAAACTCTATGAATATGCGACAAAAATGAACACTTTGGACAA
GGTCAAACAAACTCTGGAGGTCCTAGTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829IAV6

Antitoxin

Source ID Structure
AlphaFold DB A0A829IE45

References