Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1191944..1192421 Replicon chromosome
Accession NZ_CP026080
Organism Staphylococcus aureus strain FDAARGOS_12

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag RK70_RS06175 Protein ID WP_000052078.1
Coordinates 1192233..1192421 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag RK70_RS06170 Protein ID WP_001059690.1
Coordinates 1191944..1192204 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RK70_RS06135 1187337..1188053 - 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -
RK70_RS06140 1188201..1188623 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
RK70_RS06145 1189022..1189516 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
RK70_RS06150 1189671..1190288 + 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
RK70_RS06155 1190361..1190942 - 582 WP_001140693.1 phosphoglycerate mutase family protein -
RK70_RS06160 1191167..1191403 + 237 WP_000368687.1 hypothetical protein -
RK70_RS06165 1191400..1191603 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
RK70_RS06170 1191944..1192204 + 261 WP_001059690.1 hypothetical protein Antitoxin
RK70_RS06175 1192233..1192421 + 189 WP_000052078.1 hypothetical protein Toxin
RK70_RS06180 1192609..1193178 + 570 WP_001106654.1 hypothetical protein -
RK70_RS06185 1193266..1193550 + 285 WP_001004395.1 hypothetical protein -
RK70_RS06190 1193612..1193830 + 219 WP_000005886.1 hypothetical protein -
RK70_RS06195 1194326..1194526 - 201 WP_001059082.1 cold-shock protein -
RK70_RS06200 1194883..1195569 - 687 WP_001548082.1 thermonuclease family protein -
RK70_RS06205 1195910..1196380 - 471 WP_000824472.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T93233 WP_000052078.1 NZ_CP026080:1192233-1192421 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T93233 NZ_CP026080:1192233-1192421 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT93233 WP_001059690.1 NZ_CP026080:1191944-1192204 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT93233 NZ_CP026080:1191944-1192204 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References