93212

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 14144..14621 Replicon chromosome
Accession NZ_CP026079
Organism Staphylococcus aureus strain FDAARGOS_9

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag RK67_RS00110 Protein ID WP_000052076.1
Coordinates 14433..14621 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag RK67_RS00105 Protein ID WP_001059690.1
Coordinates 14144..14404 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RK67_RS00070 9537..10253 - 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -
RK67_RS00075 10401..10823 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
RK67_RS00080 11222..11716 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
RK67_RS00085 11871..12488 + 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
RK67_RS00090 12561..13142 - 582 WP_001140693.1 phosphoglycerate mutase family protein -
RK67_RS00095 13367..13603 + 237 WP_000349581.1 hypothetical protein -
RK67_RS00100 13600..13803 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
RK67_RS00105 14144..14404 + 261 WP_001059690.1 hypothetical protein Antitoxin
RK67_RS00110 14433..14621 + 189 WP_000052076.1 hypothetical protein Toxin
RK67_RS00115 14809..15378 + 570 WP_001106654.1 hypothetical protein -
RK67_RS00120 15466..15750 + 285 WP_001004399.1 hypothetical protein -
RK67_RS00125 15812..16030 + 219 WP_000005886.1 hypothetical protein -
RK67_RS00130 16522..16722 - 201 WP_001059082.1 cold-shock protein -
RK67_RS00135 17079..17765 - 687 WP_000141557.1 thermonuclease family protein -
RK67_RS00140 18106..18627 - 522 WP_000824482.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T93212 WP_000052076.1 NZ_CP026079:14433-14621 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T93212 NZ_CP026079:14433-14621 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT93212 WP_001059690.1 NZ_CP026079:14144-14404 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT93212 NZ_CP026079:14144-14404 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References