Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1551787..1552264 Replicon chromosome
Accession NZ_CP026077
Organism Staphylococcus aureus strain FDAARGOS_7

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag RK65_RS07965 Protein ID WP_000052078.1
Coordinates 1551787..1551975 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag RK65_RS07970 Protein ID WP_001059690.1
Coordinates 1552004..1552264 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RK65_RS07935 1547828..1548298 + 471 WP_000824472.1 hypothetical protein -
RK65_RS07940 1548639..1549325 + 687 WP_001548082.1 thermonuclease family protein -
RK65_RS07945 1549682..1549882 + 201 WP_001059082.1 cold-shock protein -
RK65_RS07950 1550378..1550596 - 219 WP_000005886.1 hypothetical protein -
RK65_RS07955 1550658..1550942 - 285 WP_001004395.1 hypothetical protein -
RK65_RS07960 1551030..1551599 - 570 WP_001106654.1 hypothetical protein -
RK65_RS07965 1551787..1551975 - 189 WP_000052078.1 hypothetical protein Toxin
RK65_RS07970 1552004..1552264 - 261 WP_001059690.1 hypothetical protein Antitoxin
RK65_RS07975 1552605..1552808 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
RK65_RS07980 1552805..1553041 - 237 WP_000368687.1 hypothetical protein -
RK65_RS07985 1553266..1553847 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
RK65_RS07990 1553920..1554537 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
RK65_RS07995 1554692..1555186 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
RK65_RS08000 1555585..1556007 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
RK65_RS08005 1556155..1556871 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T93208 WP_000052078.1 NZ_CP026077:c1551975-1551787 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T93208 NZ_CP026077:c1551975-1551787 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT93208 WP_001059690.1 NZ_CP026077:c1552264-1552004 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT93208 NZ_CP026077:c1552264-1552004 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References