Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1722564..1723041 Replicon chromosome
Accession NZ_CP026076
Organism Staphylococcus aureus strain FDAARGOS_4

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag RK63_RS09120 Protein ID WP_000052078.1
Coordinates 1722564..1722752 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag RK63_RS09125 Protein ID WP_001059690.1
Coordinates 1722781..1723041 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RK63_RS09090 1718605..1719075 + 471 WP_000824472.1 hypothetical protein -
RK63_RS09095 1719416..1720102 + 687 WP_001548082.1 thermonuclease family protein -
RK63_RS09100 1720459..1720659 + 201 WP_001059082.1 cold-shock protein -
RK63_RS09105 1721155..1721373 - 219 WP_000005886.1 hypothetical protein -
RK63_RS09110 1721435..1721719 - 285 WP_001004395.1 hypothetical protein -
RK63_RS09115 1721807..1722376 - 570 WP_001106654.1 hypothetical protein -
RK63_RS09120 1722564..1722752 - 189 WP_000052078.1 hypothetical protein Toxin
RK63_RS09125 1722781..1723041 - 261 WP_001059690.1 hypothetical protein Antitoxin
RK63_RS09130 1723382..1723585 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
RK63_RS09135 1723582..1723818 - 237 WP_000368687.1 hypothetical protein -
RK63_RS09140 1724043..1724624 + 582 WP_001140686.1 phosphoglycerate mutase family protein -
RK63_RS09145 1724697..1725314 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
RK63_RS09150 1725469..1725963 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
RK63_RS09155 1726362..1726784 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
RK63_RS09160 1726932..1727648 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - selk / selq 1717248..1748381 31133


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T93198 WP_000052078.1 NZ_CP026076:c1722752-1722564 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T93198 NZ_CP026076:c1722752-1722564 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT93198 WP_001059690.1 NZ_CP026076:c1723041-1722781 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT93198 NZ_CP026076:c1723041-1722781 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References