Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 2206408..2206885 Replicon chromosome
Accession NZ_CP026074
Organism Staphylococcus aureus strain FDAARGOS_47

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag RL05_RS11840 Protein ID WP_000052076.1
Coordinates 2206408..2206596 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag RL05_RS11845 Protein ID WP_001059690.1
Coordinates 2206625..2206885 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RL05_RS11810 2202402..2202923 + 522 WP_000824482.1 hypothetical protein -
RL05_RS11815 2203264..2203950 + 687 WP_000141557.1 thermonuclease family protein -
RL05_RS11820 2204307..2204507 + 201 WP_001059082.1 cold-shock protein -
RL05_RS11825 2204999..2205217 - 219 WP_000005886.1 hypothetical protein -
RL05_RS11830 2205279..2205563 - 285 WP_001004399.1 hypothetical protein -
RL05_RS11835 2205651..2206220 - 570 WP_001106654.1 hypothetical protein -
RL05_RS11840 2206408..2206596 - 189 WP_000052076.1 hypothetical protein Toxin
RL05_RS11845 2206625..2206885 - 261 WP_001059690.1 hypothetical protein Antitoxin
RL05_RS11850 2207226..2207429 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
RL05_RS11855 2207426..2207662 - 237 WP_000349581.1 hypothetical protein -
RL05_RS11860 2207887..2208468 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
RL05_RS11865 2208541..2209158 - 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
RL05_RS11870 2209313..2209807 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
RL05_RS11875 2210206..2210628 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
RL05_RS11880 2210776..2211492 + 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T93184 WP_000052076.1 NZ_CP026074:c2206596-2206408 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T93184 NZ_CP026074:c2206596-2206408 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT93184 WP_001059690.1 NZ_CP026074:c2206885-2206625 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT93184 NZ_CP026074:c2206885-2206625 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References