Detailed information of TA system TA093183

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 1746928..1747463
• Replicon: chromosome
• Accession: NZ_CP026074
• Organism: Staphylococcus aureus strain FDAARGOS_47

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: A0A4P7P340
• Locus tag: RL05_RS09460
• Protein ID: WP_001103945.1
• Coordinates: 1747140..1747463 (+)
• Length: 108 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: RL05_RS09455
• Protein ID: WP_001058486.1
• Coordinates: 1746928..1747137 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RL05_RS09420	1742141..1742383	+	243	WP_000897044.1	30S ribosomal protein S18	-
RL05_RS09425	1742499..1743605	-	1107	WP_000715303.1	Abi family protein	-
RL05_RS09430	1743786..1744997	-	1212	WP_000270133.1	site-specific integrase	-
RL05_RS09435	1745453..1746148	-	696	WP_000668213.1	helix-turn-helix domain-containing protein	-
RL05_RS09440	1746292..1746504	+	213	WP_000794656.1	helix-turn-helix transcriptional regulator	-
RL05_RS09445	1746505..1746777	+	273	WP_000091734.1	helix-turn-helix domain-containing protein	-
RL05_RS09450	1746789..1746935	+	147	WP_031824147.1	hypothetical protein	-
RL05_RS09455	1746928..1747137	+	210	WP_001058486.1	hypothetical protein	Antitoxin
RL05_RS09460	1747140..1747463	+	324	WP_001103945.1	DUF1474 family protein	Toxin
RL05_RS09465	1747528..1748397	+	870	WP_001002724.1	primase alpha helix C-terminal domain-containing protein	-
RL05_RS09470	1748411..1750120	+	1710	WP_000447455.1	DUF927 domain-containing protein	-
RL05_RS09475	1750433..1750813	+	381	WP_000356939.1	hypothetical protein	-
RL05_RS09480	1750810..1751451	+	642	WP_001019767.1	hypothetical protein	-
RL05_RS09485	1751901..1752242	+	342	WP_001190615.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1737526..1764239	26713

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-90)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 108 a.a.
• Molecular weight: 12665.26 Da
• Isoelectric Point: 4.7124

>T93183 WP_001103945.1 NZ_CP026074:1747140-1747463 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLQVYLKEFDELIQKF
HEIEKASSDVSLATESDDAKNSIKVAE

Nucleotide

• Length: 324 bp

>T93183 NZ_CP026074:1747140-1747463 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACAGGTTTATTTAAAAGAGTTCGATGAACTTATACAAAAATTT
CATGAAATAGAAAAAGCATCATCTGATGTAAGTTTGGCGACAGAATCAGATGACGCAAAGAATTCAATAAAAGTAGCAGA
GTAA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8252.31 Da
• Isoelectric Point: 4.3718

>AT93183 WP_001058486.1 NZ_CP026074:1746928-1747137 [Staphylococcus aureus]
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT93183 NZ_CP026074:1746928-1747137 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACTTGGTTTATCAACTTGAGTTAAGTGTCATGAATAATTTGGAAAGTTA
CGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGTGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Structures

Toxin

• AlphaFold DB: A0A4P7P340