Detailed information of TA system TA093164

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /HTH_XRE(antitoxin)
• Location: 15780..16577
• Replicon: chromosome
• Accession: NZ_CP026074
• Organism: Staphylococcus aureus strain FDAARGOS_47

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: RL05_RS00175
• Protein ID: WP_000525014.1
• Coordinates: 16116..16577 (+)
• Length: 154 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: RL05_RS00170
• Protein ID: WP_001260486.1
• Coordinates: 15780..16103 (+)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RL05_RS00120	11516..12073	-	558	WP_000645042.1	DUF2815 family protein	-
RL05_RS00125	12099..13265	-	1167	WP_047216521.1	DUF2800 domain-containing protein	-
RL05_RS00130	13262..13624	-	363	WP_000985976.1	hypothetical protein	-
RL05_RS00135	13639..13962	-	324	WP_000174994.1	hypothetical protein	-
RL05_RS00140	14041..14202	-	162	WP_001285963.1	DUF1270 family protein	-
RL05_RS00145	14215..14478	-	264	WP_001124190.1	helix-turn-helix domain-containing protein	-
RL05_RS00150	14503..14718	-	216	WP_001036302.1	hypothetical protein	-
RL05_RS00155	14773..15138	+	366	WP_001128433.1	hypothetical protein	-
RL05_RS00160	15107..15352	-	246	WP_001025401.1	DUF2829 domain-containing protein	-
RL05_RS00165	15368..15616	-	249	WP_000272861.1	helix-turn-helix domain-containing protein	-
RL05_RS00170	15780..16103	+	324	WP_001260486.1	helix-turn-helix domain-containing protein	Antitoxin
RL05_RS00175	16116..16577	+	462	WP_000525014.1	hypothetical protein	Toxin
RL05_RS00180	16594..17028	+	435	WP_047216523.1	hypothetical protein	-
RL05_RS00185	17057..17452	+	396	WP_000449655.1	hypothetical protein	-
RL05_RS00190	17542..17688	+	147	WP_001795334.1	hypothetical protein	-
RL05_RS00195	17685..18299	-	615	WP_000191463.1	hypothetical protein	-
RL05_RS00200	18425..19630	+	1206	WP_000264751.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (8-65)

Sequences

Toxin

Protein

• Length: 154 a.a.
• Molecular weight: 18104.44 Da
• Isoelectric Point: 4.6915

>T93164 WP_000525014.1 NZ_CP026074:16116-16577 [Staphylococcus aureus]
MGLYEETLIQHDYIEVREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVYRYKEI

Nucleotide

• Length: 462 bp

>T93164 NZ_CP026074:16116-16577 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAGTAAGAGAGGCTGATGTACTTCCAGATAATTTAGA
CGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGTTTATCAGATAGAGAAAAGGCAGGAATTCTCTTCGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGA
CGACACGGCTTTATCTCAGCTGTACCGCTACGCGAAATTGTAGAAGCTTATAATTATGGCGTACGTAACTTGTATGAGTT
GTCTGAGTATCTACAATTAAGCGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGAACTC
ACTATGGCGAGTATTCTATTACATTTGAACCGTTGAGAGTTTATCGATACAAAGAGATATAA

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 12427.10 Da
• Isoelectric Point: 9.3811

>AT93164 WP_001260486.1 NZ_CP026074:15780-16103 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQPENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK

Nucleotide

• Length: 324 bp

>AT93164 NZ_CP026074:15780-16103 [Staphylococcus aureus]
ATGAGAACTTCAGCGGAAATAGGTAAATTAATCAAACAACTACGAAAAGAAAATAATGTGAATTTAACTGATTTTGCAAC
TAAGATAGGTGTCAATAAATCTACCTTATCCCGATACGAAAACGGTAGCAGAAAAATACCTATGGAGGATATAGCTGAAA
TTGCCAATGCATTGAAAGTTACCCCAGAATATTTACTATTAAAAAATAGACAACCAGAAAACGAAGTACAACATCGTGCA
GCTCACCTTGAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGTAAACGTAA
GTAA