Detailed information of TA system TA093160

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 2792492..2793021
• Replicon: chromosome
• Accession: NZ_CP026073
• Organism: Staphylococcus aureus strain FDAARGOS_42

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: RL00_RS14480
• Protein ID: WP_000621175.1
• Coordinates: 2792659..2793021 (+)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: T1YCG8
• Locus tag: RL00_RS14475
• Protein ID: WP_000948331.1
• Coordinates: 2792492..2792662 (+)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RL00_RS14445	2787528..2788088	+	561	WP_001092409.1	K(+)-transporting ATPase subunit C	-
RL00_RS14450	2788297..2788776	+	480	WP_001287078.1	hypothetical protein	-
RL00_RS14455	2788769..2790352	+	1584	WP_001294626.1	PH domain-containing protein	-
RL00_RS14460	2790339..2790830	+	492	WP_001205912.1	PH domain-containing protein	-
RL00_RS14465	2790834..2791193	+	360	WP_000581197.1	holo-ACP synthase	-
RL00_RS14470	2791259..2792407	+	1149	WP_001281154.1	alanine racemase	-
RL00_RS14475	2792492..2792662	+	171	WP_000948331.1	type II toxin-antitoxin system antitoxin MazE	Antitoxin
RL00_RS14480	2792659..2793021	+	363	WP_000621175.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
RL00_RS14490	2793369..2794370	+	1002	WP_000390829.1	PP2C family protein-serine/threonine phosphatase	-
RL00_RS14495	2794489..2794815	+	327	WP_001052491.1	anti-sigma factor antagonist	-
RL00_RS14500	2794817..2795296	+	480	WP_001190830.1	anti-sigma B factor RsbW	-
RL00_RS14505	2795271..2796041	+	771	WP_001041108.1	RNA polymerase sigma factor SigB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-110)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13441.69 Da
• Isoelectric Point: 10.1654

>T93160 WP_000621175.1 NZ_CP026073:2792659-2793021 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Nucleotide

• Length: 363 bp

>T93160 NZ_CP026073:2792659-2793021 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAGTTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6251.78 Da
• Isoelectric Point: 3.8305

>AT93160 WP_000948331.1 NZ_CP026073:2792492-2792662 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Nucleotide

• Length: 171 bp

>AT93160 NZ_CP026073:2792492-2792662 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A0E0VRZ1