93131

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2311840..2312354 Replicon chromosome
Accession NZ_CP026072
Organism Staphylococcus aureus strain FDAARGOS_35

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag RK93_RS11990 Protein ID WP_000581792.1
Coordinates 2312145..2312354 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag RK93_RS11985 Protein ID WP_000138932.1
Coordinates 2311840..2312133 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RK93_RS11950 2307103..2307744 + 642 WP_000483153.1 thiamine phosphate synthase -
RK93_RS11955 2307830..2308702 + 873 WP_000725802.1 membrane protein insertase YidC -
RK93_RS11975 2309515..2310162 - 648 WP_001187629.1 HD domain-containing protein -
RK93_RS11980 2310190..2311674 - 1485 WP_000571549.1 cardiolipin synthase -
RK93_RS11985 2311840..2312133 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
RK93_RS11990 2312145..2312354 + 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
RK93_RS11995 2312482..2312619 + 138 WP_000828354.1 hypothetical protein -
RK93_RS12000 2312883..2314085 - 1203 WP_001109939.1 rod shape-determining protein RodA -
RK93_RS12005 2314403..2315473 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
RK93_RS12010 2315488..2316846 + 1359 WP_000611462.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T93131 WP_000581792.1 NZ_CP026072:2312145-2312354 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T93131 NZ_CP026072:2312145-2312354 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT93131 WP_000138932.1 NZ_CP026072:2311840-2312133 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT93131 NZ_CP026072:2311840-2312133 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References