Detailed information of TA system TA093122

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 1241509..1242035
• Replicon: chromosome
• Accession: NZ_CP026072
• Organism: Staphylococcus aureus strain FDAARGOS_35

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: -
• Locus tag: RK93_RS06495
• Protein ID: WP_001103949.1
• Coordinates: 1241509..1241823 (-)
• Length: 105 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: X5IY59
• Locus tag: RK93_RS06500
• Protein ID: WP_001058494.1
• Coordinates: 1241826..1242035 (-)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RK93_RS06470	1236547..1237125	-	579	WP_000846280.1	hypothetical protein	-
RK93_RS06475	1237137..1237478	-	342	WP_001190606.1	hypothetical protein	-
RK93_RS06480	1237928..1238569	-	642	WP_001019274.1	hypothetical protein	-
RK93_RS06485	1238571..1238915	-	345	WP_000567971.1	hypothetical protein	-
RK93_RS06490	1239186..1241438	-	2253	WP_000974924.1	DNA primase	-
RK93_RS06495	1241509..1241823	-	315	WP_001103949.1	DUF1474 family protein	Toxin
RK93_RS06500	1241826..1242035	-	210	WP_001058494.1	hypothetical protein	Antitoxin
RK93_RS06505	1242028..1242174	-	147	WP_000784873.1	hypothetical protein	-
RK93_RS06510	1242186..1242458	-	273	WP_001138303.1	helix-turn-helix domain-containing protein	-
RK93_RS06515	1242459..1242671	-	213	WP_001063623.1	helix-turn-helix transcriptional regulator	-
RK93_RS06520	1242821..1243555	+	735	WP_000142630.1	helix-turn-helix domain-containing protein	-
RK93_RS06525	1243854..1245068	+	1215	WP_000270128.1	site-specific integrase	-
RK93_RS06530	1245092..1245889	+	798	WP_000119675.1	type II toxin-antitoxin system PemK/MazF family toxin	-
RK93_RS06535	1246118..1246360	-	243	WP_000897044.1	30S ribosomal protein S18	-
RK93_RS06540	1246412..1246915	-	504	WP_000934799.1	single-stranded DNA-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1227420..1250978	23558

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-98)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 105 a.a.
• Molecular weight: 12374.05 Da
• Isoelectric Point: 6.2243

>T93122 WP_001103949.1 NZ_CP026072:c1241823-1241509 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVKDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFGELIQKF
HEIEKASSENFGEVSDDAKNVKKA

Nucleotide

• Length: 315 bp

>T93122 NZ_CP026072:c1241823-1241509 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTAAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACATGTGTACTTAAAAGAATTCGGTGAACTTATACAAAAATTT
CATGAAATAGAAAAAGCATCATCTGAGAACTTTGGCGAGGTATCAGATGACGCAAAGAATGTGAAAAAAGCATAA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8268.31 Da
• Isoelectric Point: 4.3718

>AT93122 WP_001058494.1 NZ_CP026072:c1242035-1241826 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVNSIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT93122 NZ_CP026072:c1242035-1241826 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTGTCATGAATAACTTGGAAAGTTA
TGAACACACAGAATATGTTAATAGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Structures

Antitoxin

• AlphaFold DB: X5IY59