93121

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 752410..752887 Replicon chromosome
Accession NZ_CP026072
Organism Staphylococcus aureus strain FDAARGOS_35

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag RK93_RS03895 Protein ID WP_000052078.1
Coordinates 752699..752887 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag RK93_RS03890 Protein ID WP_001059690.1
Coordinates 752410..752670 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RK93_RS03855 747803..748519 - 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -
RK93_RS03860 748667..749089 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
RK93_RS03865 749488..749982 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
RK93_RS03870 750137..750754 + 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
RK93_RS03875 750827..751408 - 582 WP_001140686.1 phosphoglycerate mutase family protein -
RK93_RS03880 751633..751869 + 237 WP_000368688.1 hypothetical protein -
RK93_RS03885 751866..752069 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
RK93_RS03890 752410..752670 + 261 WP_001059690.1 hypothetical protein Antitoxin
RK93_RS03895 752699..752887 + 189 WP_000052078.1 hypothetical protein Toxin
RK93_RS03900 753075..753644 + 570 WP_001106654.1 hypothetical protein -
RK93_RS03905 753732..754016 + 285 WP_001004395.1 hypothetical protein -
RK93_RS03910 754078..754296 + 219 WP_000005886.1 hypothetical protein -
RK93_RS03915 754792..754992 - 201 WP_001059082.1 cold-shock protein -
RK93_RS03920 755349..756035 - 687 WP_001548082.1 thermonuclease family protein -
RK93_RS03925 756376..756846 - 471 WP_000824472.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - seb / selq / selk / vWbp 724939..771482 46543


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T93121 WP_000052078.1 NZ_CP026072:752699-752887 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T93121 NZ_CP026072:752699-752887 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT93121 WP_001059690.1 NZ_CP026072:752410-752670 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT93121 NZ_CP026072:752410-752670 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References