Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_XRE(antitoxin)
Location 494225..495022 Replicon chromosome
Accession NZ_CP026072
Organism Staphylococcus aureus strain FDAARGOS_35

Toxin (Protein)


Gene name - Uniprot ID A0A6B0AWK0
Locus tag RK93_RS02480 Protein ID WP_000525016.1
Coordinates 494561..495022 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0C2LD36
Locus tag RK93_RS02475 Protein ID WP_001260487.1
Coordinates 494225..494548 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RK93_RS02435 490919..491182 - 264 WP_001205732.1 hypothetical protein -
RK93_RS02440 491191..491451 - 261 WP_000291503.1 DUF1108 family protein -
RK93_RS02445 491432..491758 - 327 WP_000165362.1 DUF2482 family protein -
RK93_RS02450 491853..492014 - 162 WP_000066025.1 DUF1270 domain-containing protein -
RK93_RS02455 492194..492424 + 231 WP_000395455.1 hypothetical protein -
RK93_RS02460 492600..493343 - 744 WP_001148623.1 phage antirepressor KilAC domain-containing protein -
RK93_RS02465 493408..493644 + 237 WP_000856472.1 hypothetical protein -
RK93_RS15825 493637..493798 - 162 WP_001153175.1 hypothetical protein -
RK93_RS02470 493813..494061 - 249 WP_000272858.1 helix-turn-helix domain-containing protein -
RK93_RS02475 494225..494548 + 324 WP_001260487.1 helix-turn-helix domain-containing protein Antitoxin
RK93_RS02480 494561..495022 + 462 WP_000525016.1 hypothetical protein Toxin
RK93_RS02485 495372..496757 + 1386 WP_000861313.1 recombinase family protein -
RK93_RS02490 496874..497047 - 174 WP_000290472.1 50S ribosomal protein L32 -
RK93_RS02500 497127..497684 - 558 WP_000872158.1 DUF177 domain-containing protein -
RK93_RS02505 497811..498950 + 1140 WP_000843611.1 nucleotidyltransferase -
RK93_RS02510 499012..499494 - 483 WP_000401377.1 pantetheine-phosphate adenylyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 454931..501919 46988


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(8-65)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 17993.29 Da        Isoelectric Point: 4.5941

>T93119 WP_000525016.1 NZ_CP026072:494561-495022 [Staphylococcus aureus]
MGLYEETLIQHDYIEVREADVLPDNLDGVWLGDLILIKRGLSDTEKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFTSAVPIREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

>T93119 NZ_CP026072:494561-495022 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAGTAAGAGAGGCTGATGTACTTCCAGATAATTTAGA
CGGGGTATGGTTAGGAGATCTAATTTTAATAAAGCGTGGTTTATCAGATACAGAAAAGGCAGGAATTCTCTTCGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCTGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTATGCACGT
AGACATGGTTTTACTTCAGCTGTACCGATACGTGAAATTGTAGAAGCTTACAATTATGGCGTACGTAACTTGTATGAGTT
GTCTGAGTATCTACAATTAAGCGAAGAATACATATTGGAGGCAATAGAACAATATAAGAAGATATACGGTATTGGAACTC
ACTATGGCGAGTATTCGATTACATTTGAGCCGTTGAGAGTTTTTAAATATAAAGAAATATGA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12431.09 Da        Isoelectric Point: 9.3811

>AT93119 WP_001260487.1 NZ_CP026072:494225-494548 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK

Download         Length: 324 bp

>AT93119 NZ_CP026072:494225-494548 [Staphylococcus aureus]
ATGAGAACTTCAGCAGAAATAGGTAAATTAATCAAACAACTACGAAAAGAGAATAATGTGAATTTAACTGATTTTGCAAC
TAAGATAGGTGTCAATAAATCTACCTTATCCCGATATGAAAACGGTAGCAGAAAAATACCTATGGAGGATATAGCTGAAA
TTGCCAATGCATTGAAAGTTACCCCAGAATATTTACTATTAAAAAATAGACAAACAGAAAACGAAGTACAACATCGAGCA
GCTCACCTTGAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGTAAACGTAA
GTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6B0AWK0

Antitoxin

Source ID Structure
AlphaFold DB A0A0C2LD36

References