Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1357196..1357673 Replicon chromosome
Accession NZ_CP026071
Organism Staphylococcus aureus strain FDAARGOS_30

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag RK88_RS07130 Protein ID WP_000052076.1
Coordinates 1357485..1357673 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag RK88_RS07125 Protein ID WP_001059690.1
Coordinates 1357196..1357456 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RK88_RS07090 1352587..1353303 - 717 WP_000150036.1 type I 3-dehydroquinate dehydratase -
RK88_RS07095 1353451..1353873 + 423 WP_042904984.1 organic hydroperoxide resistance protein -
RK88_RS07100 1354272..1354766 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
RK88_RS07105 1354923..1355540 + 618 WP_042904985.1 LysE/ArgO family amino acid transporter -
RK88_RS07110 1355613..1356194 - 582 WP_001140696.1 phosphoglycerate mutase family protein -
RK88_RS07115 1356419..1356655 + 237 WP_000368687.1 hypothetical protein -
RK88_RS07120 1356652..1356855 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
RK88_RS07125 1357196..1357456 + 261 WP_001059690.1 hypothetical protein Antitoxin
RK88_RS07130 1357485..1357673 + 189 WP_000052076.1 hypothetical protein Toxin
RK88_RS07135 1357861..1358430 + 570 WP_001106663.1 hypothetical protein -
RK88_RS07140 1358518..1358802 + 285 WP_001004401.1 hypothetical protein -
RK88_RS07145 1358864..1359082 + 219 WP_000005879.1 hypothetical protein -
RK88_RS07150 1359579..1359779 - 201 WP_001059082.1 cold-shock protein -
RK88_RS07155 1360136..1360822 - 687 WP_001574556.1 thermonuclease family protein -
RK88_RS07160 1361163..1361720 - 558 WP_000824491.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-132)

Antitoxin

Flavinator of succinate dehydrogenase

(8-79)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T93106 WP_000052076.1 NZ_CP026071:1357485-1357673 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T93106 NZ_CP026071:1357485-1357673 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTCGGATTCGCTATTTTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT93106 WP_001059690.1 NZ_CP026071:1357196-1357456 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT93106 NZ_CP026071:1357196-1357456 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References