Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 68984..69513 Replicon chromosome
Accession NZ_CP026071
Organism Staphylococcus aureus strain FDAARGOS_30

Toxin (Protein)


Gene name mazF Uniprot ID Q6GF05
Locus tag RK88_RS00395 Protein ID WP_000621176.1
Coordinates 69151..69513 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag RK88_RS00390 Protein ID WP_000948331.1
Coordinates 68984..69154 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RK88_RS00360 64020..64580 + 561 WP_001092414.1 K(+)-transporting ATPase subunit C -
RK88_RS00365 64789..65268 + 480 WP_001287082.1 hypothetical protein -
RK88_RS00370 65261..66838 + 1578 WP_001294646.1 PH domain-containing protein -
RK88_RS00375 66831..67322 + 492 WP_001286801.1 PH domain-containing protein -
RK88_RS00380 67326..67685 + 360 WP_000581197.1 holo-ACP synthase -
RK88_RS00385 67751..68899 + 1149 WP_001281140.1 alanine racemase -
RK88_RS00390 68984..69154 + 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
RK88_RS00395 69151..69513 + 363 WP_000621176.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
RK88_RS00405 69862..70863 + 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
RK88_RS00410 70982..71308 + 327 WP_001052491.1 anti-sigma factor antagonist -
RK88_RS00415 71310..71789 + 480 WP_001190825.1 anti-sigma B factor RsbW -
RK88_RS00420 71764..72534 + 771 WP_001041107.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13469.74 Da        Isoelectric Point: 10.1654

>T93095 WP_000621176.1 NZ_CP026071:69151-69513 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVVHQKN

Download         Length: 363 bp

>T93095 NZ_CP026071:69151-69513 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAACAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAGCAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACATACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGTTCATCAGAAAAATTAG

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT93095 WP_000948331.1 NZ_CP026071:68984-69154 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT93095 NZ_CP026071:68984-69154 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A168PYX0

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References