Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 223444..223921 Replicon chromosome
Accession NZ_CP026070
Organism Staphylococcus aureus strain FDAARGOS_27

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag RK85_RS01175 Protein ID WP_000052078.1
Coordinates 223733..223921 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag RK85_RS01170 Protein ID WP_001059690.1
Coordinates 223444..223704 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RK85_RS01135 218837..219553 - 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -
RK85_RS01140 219701..220123 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
RK85_RS01145 220522..221016 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
RK85_RS01150 221171..221788 + 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
RK85_RS01155 221861..222442 - 582 WP_001140693.1 phosphoglycerate mutase family protein -
RK85_RS01160 222667..222903 + 237 WP_000368687.1 hypothetical protein -
RK85_RS01165 222900..223103 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
RK85_RS01170 223444..223704 + 261 WP_001059690.1 hypothetical protein Antitoxin
RK85_RS01175 223733..223921 + 189 WP_000052078.1 hypothetical protein Toxin
RK85_RS01180 224109..224678 + 570 WP_001106654.1 hypothetical protein -
RK85_RS01185 224766..225050 + 285 WP_001004395.1 hypothetical protein -
RK85_RS01190 225112..225330 + 219 WP_000005886.1 hypothetical protein -
RK85_RS01195 225826..226026 - 201 WP_001059082.1 cold-shock protein -
RK85_RS01200 226383..227069 - 687 WP_001548082.1 thermonuclease family protein -
RK85_RS01205 227410..227880 - 471 WP_000824472.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Antitoxin MqsA/HigA-2

(1-131)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T93077 WP_000052078.1 NZ_CP026070:223733-223921 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T93077 NZ_CP026070:223733-223921 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT93077 WP_001059690.1 NZ_CP026070:223444-223704 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT93077 NZ_CP026070:223444-223704 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References