Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 2653943..2654420 Replicon chromosome
Accession NZ_CP026069
Organism Staphylococcus aureus strain FDAARGOS_25

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag RK83_RS13855 Protein ID WP_000052076.1
Coordinates 2654232..2654420 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag RK83_RS13850 Protein ID WP_001059690.1
Coordinates 2653943..2654203 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RK83_RS13815 2649336..2650052 - 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -
RK83_RS13820 2650200..2650622 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
RK83_RS13825 2651021..2651515 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
RK83_RS13830 2651670..2652287 + 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
RK83_RS13835 2652360..2652941 - 582 WP_001140693.1 phosphoglycerate mutase family protein -
RK83_RS13840 2653166..2653402 + 237 WP_000349581.1 hypothetical protein -
RK83_RS13845 2653399..2653602 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
RK83_RS13850 2653943..2654203 + 261 WP_001059690.1 hypothetical protein Antitoxin
RK83_RS13855 2654232..2654420 + 189 WP_000052076.1 hypothetical protein Toxin
RK83_RS13860 2654608..2655177 + 570 WP_001106654.1 hypothetical protein -
RK83_RS13865 2655265..2655549 + 285 WP_001004399.1 hypothetical protein -
RK83_RS13870 2655611..2655829 + 219 WP_000005886.1 hypothetical protein -
RK83_RS13875 2656321..2656521 - 201 WP_001059082.1 cold-shock protein -
RK83_RS13880 2656878..2657564 - 687 WP_000141557.1 thermonuclease family protein -
RK83_RS13885 2657905..2658426 - 522 WP_000824482.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Entericidin A/B

(23-42)

Antitoxin

Entericidin A/B

(23-42)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T93071 WP_000052076.1 NZ_CP026069:2654232-2654420 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T93071 NZ_CP026069:2654232-2654420 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT93071 WP_001059690.1 NZ_CP026069:2653943-2654203 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT93071 NZ_CP026069:2653943-2654203 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References