Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 1405862..1406391 Replicon chromosome
Accession NZ_CP026069
Organism Staphylococcus aureus strain FDAARGOS_25

Toxin (Protein)


Gene name TscT Uniprot ID K7ZRX2
Locus tag RK83_RS07155 Protein ID WP_001103933.1
Coordinates 1406074..1406391 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID A0A6B0BJC0
Locus tag RK83_RS07150 Protein ID WP_001058487.1
Coordinates 1405862..1406071 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RK83_RS07115 1402313..1402777 + 465 WP_001085183.1 SsrA-binding protein SmpB -
RK83_RS07125 1403340..1404446 - 1107 WP_000121223.1 site-specific integrase -
RK83_RS07130 1404452..1405099 - 648 WP_072474260.1 helix-turn-helix domain-containing protein -
RK83_RS07135 1405257..1405463 + 207 WP_001060953.1 hypothetical protein -
RK83_RS07140 1405499..1405726 + 228 WP_000164237.1 helix-turn-helix domain-containing protein -
RK83_RS07145 1405723..1405869 + 147 WP_000784893.1 hypothetical protein -
RK83_RS07150 1405862..1406071 + 210 WP_001058487.1 hypothetical protein Antitoxin
RK83_RS07155 1406074..1406391 + 318 WP_001103933.1 DUF1474 family protein Toxin
RK83_RS07160 1406458..1407327 + 870 WP_001002695.1 primase alpha helix C-terminal domain-containing protein -
RK83_RS07165 1407344..1408813 + 1470 WP_001668899.1 virulence-associated E family protein -
RK83_RS07175 1409099..1409461 + 363 WP_001039169.1 hypothetical protein -
RK83_RS07180 1409463..1409747 + 285 WP_000998179.1 hypothetical protein -
RK83_RS07185 1409744..1410385 + 642 WP_001019810.1 hypothetical protein -
RK83_RS07190 1410835..1411176 + 342 WP_001190615.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - tsst-1 / sec / sell / hlb / sea / sak / scn 1403340..1467541 64201


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-98)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12511.13 Da        Isoelectric Point: 4.6364

>T93064 WP_001103933.1 NZ_CP026069:1406074-1406391 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKEKINDVAIKHGWFVEDKFVKNELETKQEHINFSASYLEHRIQNEHTVELLQVYLKEFGELIQKF
HEIEKASSENFGEESDDAKKLKITE

Download         Length: 318 bp

>T93064 NZ_CP026069:1406074-1406391 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTGATGTGTGATATTGAAGTGATAAAAGAAAAAATCAATGATGTAGCTATCAAACATGG
TTGGTTTGTTGAAGATAAATTTGTCAAAAATGAATTAGAAACAAAACAGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACAGGTGTACTTAAAAGAATTCGGTGAACTTATACAAAAGTTT
CATGAAATAGAAAAAGCATCATCTGAGAACTTTGGCGAGGAATCAGATGACGCAAAGAAATTAAAAATTACAGAGTAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8228.24 Da        Isoelectric Point: 4.1682

>AT93064 WP_001058487.1 NZ_CP026069:1405862-1406071 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSIMNNFESYEHTEYVDGIEVVSEISPEKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT93064 NZ_CP026069:1405862-1406071 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTATCATGAATAATTTTGAAAGTTA
TGAACACACGGAATATGTTGATGGTATTGAAGTGGTTTCAGAGATCAGTCCTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAAAAAGGAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K7ZRX2

Antitoxin

Source ID Structure
AlphaFold DB A0A6B0BJC0

References