Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 312402..312879 Replicon chromosome
Accession NZ_CP026068
Organism Staphylococcus aureus strain FDAARGOS_24

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag RK82_RS01580 Protein ID WP_000052078.1
Coordinates 312402..312590 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag RK82_RS01585 Protein ID WP_001059690.1
Coordinates 312619..312879 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RK82_RS01550 308443..308913 + 471 WP_000824472.1 hypothetical protein -
RK82_RS01555 309254..309940 + 687 WP_001548082.1 thermonuclease family protein -
RK82_RS01560 310297..310497 + 201 WP_001059082.1 cold-shock protein -
RK82_RS01565 310993..311211 - 219 WP_000005886.1 hypothetical protein -
RK82_RS01570 311273..311557 - 285 WP_001004395.1 hypothetical protein -
RK82_RS01575 311645..312214 - 570 WP_001106654.1 hypothetical protein -
RK82_RS01580 312402..312590 - 189 WP_000052078.1 hypothetical protein Toxin
RK82_RS01585 312619..312879 - 261 WP_001059690.1 hypothetical protein Antitoxin
RK82_RS01590 313220..313423 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
RK82_RS01595 313420..313656 - 237 WP_000368687.1 hypothetical protein -
RK82_RS01600 313881..314462 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
RK82_RS01605 314535..315152 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
RK82_RS01610 315307..315801 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
RK82_RS01615 316200..316622 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
RK82_RS01620 316770..317486 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-94)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T93049 WP_000052078.1 NZ_CP026068:c312590-312402 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T93049 NZ_CP026068:c312590-312402 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT93049 WP_001059690.1 NZ_CP026068:c312879-312619 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT93049 NZ_CP026068:c312879-312619 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References