Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2720938..2721452 Replicon chromosome
Accession NZ_CP026067
Organism Staphylococcus aureus strain FDAARGOS_21

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag RK79_RS14085 Protein ID WP_000581792.1
Coordinates 2720938..2721147 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag RK79_RS14090 Protein ID WP_000138932.1
Coordinates 2721159..2721452 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RK79_RS14065 2716446..2717804 - 1359 WP_047213666.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
RK79_RS14070 2717819..2718889 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
RK79_RS14075 2719207..2720409 + 1203 WP_001109939.1 rod shape-determining protein RodA -
RK79_RS14080 2720673..2720810 - 138 WP_000828354.1 hypothetical protein -
RK79_RS14085 2720938..2721147 - 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
RK79_RS14090 2721159..2721452 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
RK79_RS14095 2721618..2723102 + 1485 WP_000571551.1 cardiolipin synthase -
RK79_RS14100 2723130..2723777 + 648 WP_001187620.1 HD domain-containing protein -
RK79_RS14115 2724408..2725280 - 873 WP_000725802.1 membrane protein insertase YidC -
RK79_RS14120 2725366..2726007 - 642 WP_000483160.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T93046 WP_000581792.1 NZ_CP026067:c2721147-2720938 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T93046 NZ_CP026067:c2721147-2720938 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGACGGTCAAGTAACTGTATCGTATGAGACGCCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT93046 WP_000138932.1 NZ_CP026067:c2721452-2721159 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT93046 NZ_CP026067:c2721452-2721159 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAAGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References