Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 2471406..2472182 Replicon chromosome
Accession NZ_CP026067
Organism Staphylococcus aureus strain FDAARGOS_21

Toxin (Protein)


Gene name tsbT Uniprot ID A0A380DXA2
Locus tag RK79_RS12525 Protein ID WP_000031110.1
Coordinates 2471406..2471558 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A0D1IYN8
Locus tag RK79_RS12530 Protein ID WP_001251219.1
Coordinates 2471583..2472182 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RK79_RS12505 2467499..2468320 + 822 WP_000669377.1 RluA family pseudouridine synthase -
RK79_RS12510 2468770..2470155 - 1386 WP_000116225.1 class II fumarate hydratase -
RK79_RS12515 2470351..2470746 - 396 WP_000901023.1 hypothetical protein -
RK79_RS12525 2471406..2471558 - 153 WP_000031110.1 hypothetical protein Toxin
RK79_RS12530 2471583..2472182 - 600 WP_001251219.1 glucosamine-6-phosphate isomerase Antitoxin
RK79_RS12535 2472341..2472811 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
RK79_RS12540 2472816..2473943 - 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
RK79_RS12545 2474094..2474816 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
RK79_RS12550 2474809..2476266 - 1458 WP_047213583.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5964.34 Da        Isoelectric Point: 3.9953

>T93041 WP_000031110.1 NZ_CP026067:c2471558-2471406 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMERISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T93041 NZ_CP026067:c2471558-2471406 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACTGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACGAATTTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22357.50 Da        Isoelectric Point: 5.1445

>AT93041 WP_001251219.1 NZ_CP026067:c2472182-2471583 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT93041 NZ_CP026067:c2472182-2471583 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACTGATCAAGCGCCAGTACTAGATGAATTAAAGAAAAATATTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACTGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A380DXA2

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1IYN8

References