Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1300413..1300890 Replicon chromosome
Accession NZ_CP026067
Organism Staphylococcus aureus strain FDAARGOS_21

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag RK79_RS06425 Protein ID WP_000052076.1
Coordinates 1300413..1300601 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag RK79_RS06430 Protein ID WP_001059690.1
Coordinates 1300630..1300890 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RK79_RS06395 1296441..1296923 + 483 WP_000824492.1 hypothetical protein -
RK79_RS06400 1297264..1297950 + 687 WP_000141556.1 thermonuclease family protein -
RK79_RS06405 1298307..1298507 + 201 WP_001059082.1 cold-shock protein -
RK79_RS06410 1299004..1299222 - 219 WP_000005883.1 hypothetical protein -
RK79_RS06415 1299284..1299568 - 285 WP_001004397.1 hypothetical protein -
RK79_RS06420 1299656..1300225 - 570 WP_001106648.1 hypothetical protein -
RK79_RS06425 1300413..1300601 - 189 WP_000052076.1 hypothetical protein Toxin
RK79_RS06430 1300630..1300890 - 261 WP_001059690.1 hypothetical protein Antitoxin
RK79_RS06435 1301231..1301434 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
RK79_RS06440 1301431..1301667 - 237 WP_000368687.1 hypothetical protein -
RK79_RS06445 1301892..1302473 + 582 WP_047213250.1 phosphoglycerate mutase family protein -
RK79_RS06450 1302546..1303163 - 618 WP_047213256.1 LysE/ArgO family amino acid transporter -
RK79_RS06455 1303320..1303814 - 495 WP_000569881.1 GNAT family N-acetyltransferase -
RK79_RS06460 1304213..1304635 - 423 WP_031927537.1 organic hydroperoxide resistance protein -
RK79_RS06465 1304783..1305499 + 717 WP_031927536.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-67)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T93036 WP_000052076.1 NZ_CP026067:c1300601-1300413 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T93036 NZ_CP026067:c1300601-1300413 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAATCCTATTTAAGTTTCACTGTCATTCTCTATATTTTCGGATTCGCTATTTTAA
TATACACATTTATATTTGGTGTACTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT93036 WP_001059690.1 NZ_CP026067:c1300890-1300630 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT93036 NZ_CP026067:c1300890-1300630 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATTGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References