Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2718535..2719064 Replicon chromosome
Accession NZ_CP026066
Organism Staphylococcus aureus strain FDAARGOS_20

Toxin (Protein)


Gene name mazF Uniprot ID Q6GF05
Locus tag RK78_RS13870 Protein ID WP_000621176.1
Coordinates 2718535..2718897 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag RK78_RS13875 Protein ID WP_000948331.1
Coordinates 2718894..2719064 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RK78_RS13845 2715513..2716283 - 771 WP_001041107.1 RNA polymerase sigma factor SigB -
RK78_RS13850 2716258..2716737 - 480 WP_001190825.1 anti-sigma B factor RsbW -
RK78_RS13855 2716739..2717065 - 327 WP_001052491.1 anti-sigma factor antagonist -
RK78_RS13860 2717184..2718185 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
RK78_RS13870 2718535..2718897 - 363 WP_000621176.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
RK78_RS13875 2718894..2719064 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
RK78_RS13880 2719149..2720297 - 1149 WP_001281140.1 alanine racemase -
RK78_RS13885 2720363..2720722 - 360 WP_000581197.1 holo-ACP synthase -
RK78_RS13890 2720726..2721217 - 492 WP_001286801.1 PH domain-containing protein -
RK78_RS13895 2721210..2722787 - 1578 WP_001294646.1 PH domain-containing protein -
RK78_RS13900 2722780..2723259 - 480 WP_001287082.1 hypothetical protein -
RK78_RS13905 2723468..2724028 - 561 WP_001092414.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13469.74 Da        Isoelectric Point: 10.1654

>T93028 WP_000621176.1 NZ_CP026066:c2718897-2718535 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVVHQKN

Download         Length: 363 bp

>T93028 NZ_CP026066:c2718897-2718535 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAACAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAGCAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACATACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGTTCATCAGAAAAATTAG

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT93028 WP_000948331.1 NZ_CP026066:c2719064-2718894 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT93028 NZ_CP026066:c2719064-2718894 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A168PYX0

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References