Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 2164337..2165125 Replicon chromosome
Accession NZ_CP026066
Organism Staphylococcus aureus strain FDAARGOS_20

Toxin (Protein)


Gene name - Uniprot ID A0A2I7Y5B3
Locus tag RK78_RS10870 Protein ID WP_000525004.1
Coordinates 2164664..2165125 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0E7YIA0
Locus tag RK78_RS10865 Protein ID WP_000333630.1
Coordinates 2164337..2164651 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RK78_RS10805 2159479..2160645 - 1167 WP_000762532.1 DUF2800 domain-containing protein -
RK78_RS10810 2160642..2161004 - 363 WP_000279449.1 hypothetical protein -
RK78_RS10815 2161019..2161342 - 324 WP_000175000.1 hypothetical protein -
RK78_RS10820 2161421..2161582 - 162 WP_001285963.1 DUF1270 family protein -
RK78_RS10825 2161595..2161858 - 264 WP_001124190.1 helix-turn-helix domain-containing protein -
RK78_RS10830 2161883..2162098 - 216 WP_001036302.1 hypothetical protein -
RK78_RS10835 2162153..2162518 + 366 WP_001128433.1 hypothetical protein -
RK78_RS10840 2162487..2162732 - 246 WP_000701494.1 DUF2829 domain-containing protein -
RK78_RS10845 2162788..2162997 + 210 WP_000642492.1 hypothetical protein -
RK78_RS10850 2162987..2163130 - 144 WP_000939498.1 hypothetical protein -
RK78_RS10855 2163159..2163935 - 777 WP_001148544.1 Rha family transcriptional regulator -
RK78_RS10860 2163949..2164185 - 237 WP_001121027.1 helix-turn-helix domain-containing protein -
RK78_RS10865 2164337..2164651 + 315 WP_000333630.1 helix-turn-helix domain-containing protein Antitoxin
RK78_RS10870 2164664..2165125 + 462 WP_000525004.1 hypothetical protein Toxin
RK78_RS10875 2165143..2165727 + 585 WP_000825948.1 hypothetical protein -
RK78_RS10880 2165957..2166103 + 147 WP_001013104.1 hypothetical protein -
RK78_RS10885 2166100..2166714 - 615 WP_000191459.1 hypothetical protein -
RK78_RS10890 2166840..2168045 + 1206 WP_000264747.1 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - lukF-PV / lukS-PV 2121977..2180820 58843


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(4-62)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18074.46 Da        Isoelectric Point: 4.6915

>T93021 WP_000525004.1 NZ_CP026066:2164664-2165125 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

>T93021 NZ_CP026066:2164664-2165125 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTGCTTCCAGATAATTTGGA
TGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGCTTATCAGATAGAGAAAAGGCAGGAATTCTCTTTGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGG
CGACACGGCTTTATCTCAGCAGTCCCGTTACGCGAAATTGTGGAAGCTTACAATTATGGTGTACGTAACTTGTATGAGTT
GTCTGAGTATCTGCAATTGAGTGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGGACTC
ACTACGGCGAATACTCAATTACATTTGAGCCATTGAGAGTTTTTAAATATAAAGAAATATAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12063.56 Da        Isoelectric Point: 6.4736

>AT93021 WP_000333630.1 NZ_CP026066:2164337-2164651 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK

Download         Length: 315 bp

>AT93021 NZ_CP026066:2164337-2164651 [Staphylococcus aureus]
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAAACAAGGTATGACTTTGGCCGAACTAGGAAGAAAAATTGGTAA
AACTGAAGCTACTGTACAGCGTTATGAAAGCGGAAATATCAAAAATTTAAAAAACGATACTATAGAAAGTATAGCTACTG
CATTAAATGTTAATCCTGCATATTTAATGGGGTGGGTTGAAGAAAACGATGATGAAGTACAACATCGTGCAGCTCACCTT
GAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGCAAACGTAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y5B3

Antitoxin

Source ID Structure
AlphaFold DB A0A0E7YIA0

References