Detailed information of TA system TA093016

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 1414184..1414661
• Replicon: chromosome
• Accession: NZ_CP026066
• Organism: Staphylococcus aureus strain FDAARGOS_20

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: -
• Locus tag: RK78_RS07055
• Protein ID: WP_047211747.1
• Coordinates: 1414184..1414372 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: RK78_RS07060
• Protein ID: WP_001059690.1
• Coordinates: 1414401..1414661 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RK78_RS07025	1410137..1410694	+	558	WP_000824491.1	hypothetical protein	-
RK78_RS07030	1411035..1411721	+	687	WP_001574556.1	thermonuclease family protein	-
RK78_RS07035	1412078..1412278	+	201	WP_001059082.1	cold-shock protein	-
RK78_RS07040	1412775..1412993	-	219	WP_000005879.1	hypothetical protein	-
RK78_RS07045	1413055..1413339	-	285	WP_001004401.1	hypothetical protein	-
RK78_RS07050	1413427..1413996	-	570	WP_001106663.1	hypothetical protein	-
RK78_RS07055	1414184..1414372	-	189	WP_047211747.1	hypothetical protein	Toxin
RK78_RS07060	1414401..1414661	-	261	WP_001059690.1	hypothetical protein	Antitoxin
RK78_RS07065	1415002..1415205	+	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
RK78_RS07070	1415202..1415438	-	237	WP_000368687.1	hypothetical protein	-
RK78_RS07075	1415663..1416244	+	582	WP_001140696.1	phosphoglycerate mutase family protein	-
RK78_RS07080	1416317..1416934	-	618	WP_000255548.1	LysE/ArgO family amino acid transporter	-
RK78_RS07085	1417090..1417584	-	495	WP_000569884.1	GNAT family N-acetyltransferase	-
RK78_RS07090	1417983..1418405	-	423	WP_000974455.1	organic hydroperoxide resistance protein	-
RK78_RS07095	1418553..1419269	+	717	WP_000150025.1	type I 3-dehydroquinate dehydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (13-92)

Antitoxin

• Cro/C1-type helix-turn-helix domain (17-69)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7172.90 Da
• Isoelectric Point: 9.9971

>T93016 WP_047211747.1 NZ_CP026066:c1414372-1414184 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAAMFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T93016 NZ_CP026066:c1414372-1414184 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTATGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTCGGATTCGCTATTTTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT93016 WP_001059690.1 NZ_CP026066:c1414661-1414401 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT93016 NZ_CP026066:c1414661-1414401 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Structures

Antitoxin

• AlphaFold DB: A0A0E0VN56