Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2139045..2139574 Replicon chromosome
Accession NZ_CP026064
Organism Staphylococcus aureus strain FDAARGOS_19

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag RK77_RS10725 Protein ID WP_000621175.1
Coordinates 2139212..2139574 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag RK77_RS10720 Protein ID WP_000948330.1
Coordinates 2139045..2139215 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RK77_RS10690 2134081..2134641 + 561 WP_001092400.1 K(+)-transporting ATPase subunit C -
RK77_RS10695 2134850..2135329 + 480 WP_001287080.1 hypothetical protein -
RK77_RS10700 2135322..2136905 + 1584 WP_001294624.1 PH domain-containing protein -
RK77_RS10705 2136892..2137383 + 492 WP_001205918.1 PH domain-containing protein -
RK77_RS10710 2137387..2137746 + 360 WP_000581193.1 holo-ACP synthase -
RK77_RS10715 2137812..2138960 + 1149 WP_001281141.1 alanine racemase -
RK77_RS10720 2139045..2139215 + 171 WP_000948330.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
RK77_RS10725 2139212..2139574 + 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
RK77_RS10735 2139923..2140924 + 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
RK77_RS10740 2141044..2141370 + 327 WP_001052491.1 anti-sigma factor antagonist -
RK77_RS10745 2141372..2141851 + 480 WP_001190825.1 anti-sigma B factor RsbW -
RK77_RS10750 2141826..2142596 + 771 WP_001041107.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T92999 WP_000621175.1 NZ_CP026064:2139212-2139574 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

>T92999 NZ_CP026064:2139212-2139574 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATTATTCAAAATGACACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAATATAAATTGGATAAAGACTCAGTCATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTATTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCATCAGAAAAATTAG

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6237.75 Da        Isoelectric Point: 3.8305

>AT92999 WP_000948330.1 NZ_CP026064:2139045-2139215 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNESYLSSNSTNE

Download         Length: 171 bp

>AT92999 NZ_CP026064:2139045-2139215 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAATCATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References