Detailed information of TA system TA092998

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsdAT/-
• Location: 2119304..2119818
• Replicon: chromosome
• Accession: NZ_CP026064
• Organism: Staphylococcus aureus strain FDAARGOS_19

Toxin (Protein)

• Gene name: TsdT
• Uniprot ID: T1YA99
• Locus tag: RK77_RS10635
• Protein ID: WP_000581792.1
• Coordinates: 2119609..2119818 (+)
• Length: 70 a.a.

Antitoxin (Protein)

• Gene name: TsdA
• Uniprot ID: -
• Locus tag: RK77_RS10630
• Protein ID: WP_000138928.1
• Coordinates: 2119304..2119597 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RK77_RS10605	2114902..2115543	+	642	WP_000483153.1	thiamine phosphate synthase	-
RK77_RS10610	2115629..2116501	+	873	WP_000725802.1	membrane protein insertase YidC	-
RK77_RS10620	2116979..2117626	-	648	WP_001187617.1	HD domain-containing protein	-
RK77_RS10625	2117654..2119138	-	1485	WP_000571551.1	cardiolipin synthase	-
RK77_RS10630	2119304..2119597	+	294	WP_000138928.1	copper-sensing transcriptional repressor CsoR	Antitoxin
RK77_RS10635	2119609..2119818	+	210	WP_000581792.1	heavy-metal-associated domain-containing protein	Toxin
RK77_RS10640	2119946..2120083	+	138	WP_000828354.1	hypothetical protein	-
RK77_RS10645	2120347..2121549	-	1203	WP_001109944.1	rod shape-determining protein RodA	-
RK77_RS10650	2121867..2122937	+	1071	WP_000159632.1	D-alanine--D-alanine ligase	-
RK77_RS10655	2122952..2124310	+	1359	WP_000611469.1	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Heavy metal-associated domain, HMA (23-66)

Antitoxin

• Metal-sensitive transcriptional repressor (14-92)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 7843.77 Da
• Isoelectric Point: 4.1008

>T92998 WP_000581792.1 NZ_CP026064:2119609-2119818 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Nucleotide

• Length: 210 bp

>T92998 NZ_CP026064:2119609-2119818 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGACGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11184.82 Da
• Isoelectric Point: 6.2243

>AT92998 WP_000138928.1 NZ_CP026064:2119304-2119597 [Staphylococcus aureus]
MTEQDIAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Nucleotide

• Length: 294 bp

>AT92998 NZ_CP026064:2119304-2119597 [Staphylococcus aureus]
ATGACTGAACAAGATATTGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGACAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Structures

Toxin

• PDB: 6FF1