Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 617797..618274 Replicon chromosome
Accession NZ_CP026064
Organism Staphylococcus aureus strain FDAARGOS_19

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag RK77_RS03085 Protein ID WP_000052076.1
Coordinates 618086..618274 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag RK77_RS03080 Protein ID WP_001059690.1
Coordinates 617797..618057 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RK77_RS03045 613192..613908 - 717 WP_000150015.1 type I 3-dehydroquinate dehydratase -
RK77_RS03050 614056..614478 + 423 WP_000974455.1 organic hydroperoxide resistance protein -
RK77_RS03055 614877..615371 + 495 WP_000590539.1 GNAT family N-acetyltransferase -
RK77_RS03060 615525..616142 + 618 WP_000255559.1 LysE/ArgO family amino acid transporter -
RK77_RS03065 616215..616796 - 582 WP_001140696.1 phosphoglycerate mutase family protein -
RK77_RS03070 617021..617257 + 237 WP_000368687.1 hypothetical protein -
RK77_RS03075 617254..617457 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
RK77_RS03080 617797..618057 + 261 WP_001059690.1 hypothetical protein Antitoxin
RK77_RS03085 618086..618274 + 189 WP_000052076.1 hypothetical protein Toxin
RK77_RS03090 618462..619031 + 570 WP_001106646.1 hypothetical protein -
RK77_RS03095 619119..619403 + 285 WP_001004395.1 hypothetical protein -
RK77_RS03100 619465..619683 + 219 WP_000005876.1 hypothetical protein -
RK77_RS03105 620179..620379 - 201 WP_001059082.1 cold-shock protein -
RK77_RS03110 620736..621422 - 687 WP_001670297.1 thermonuclease family protein -
RK77_RS03115 621763..622284 - 522 WP_000824488.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T92989 WP_000052076.1 NZ_CP026064:618086-618274 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T92989 NZ_CP026064:618086-618274 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTTACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT92989 WP_001059690.1 NZ_CP026064:617797-618057 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT92989 NZ_CP026064:617797-618057 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References