Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1677094..1677571 Replicon chromosome
Accession NZ_CP026063
Organism Staphylococcus aureus strain FDAARGOS_14

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag RK72_RS08735 Protein ID WP_000052076.1
Coordinates 1677094..1677282 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag RK72_RS08740 Protein ID WP_001059690.1
Coordinates 1677311..1677571 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RK72_RS08705 1673087..1673608 + 522 WP_000824482.1 hypothetical protein -
RK72_RS08710 1673949..1674635 + 687 WP_000141557.1 thermonuclease family protein -
RK72_RS08715 1674992..1675192 + 201 WP_001059082.1 cold-shock protein -
RK72_RS08720 1675685..1675903 - 219 WP_000005886.1 hypothetical protein -
RK72_RS08725 1675965..1676249 - 285 WP_001004399.1 hypothetical protein -
RK72_RS08730 1676337..1676906 - 570 WP_001106654.1 hypothetical protein -
RK72_RS08735 1677094..1677282 - 189 WP_000052076.1 hypothetical protein Toxin
RK72_RS08740 1677311..1677571 - 261 WP_001059690.1 hypothetical protein Antitoxin
RK72_RS08745 1677912..1678115 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
RK72_RS08750 1678112..1678348 - 237 WP_000349581.1 hypothetical protein -
RK72_RS08755 1678573..1679154 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
RK72_RS08760 1679227..1679844 - 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
RK72_RS08765 1679999..1680493 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
RK72_RS08770 1680892..1681314 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
RK72_RS08775 1681462..1682178 + 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T92985 WP_000052076.1 NZ_CP026063:c1677282-1677094 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T92985 NZ_CP026063:c1677282-1677094 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT92985 WP_001059690.1 NZ_CP026063:c1677571-1677311 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT92985 NZ_CP026063:c1677571-1677311 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References