Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 207454..207968 Replicon chromosome
Accession NZ_CP026063
Organism Staphylococcus aureus strain FDAARGOS_14

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag RK72_RS01275 Protein ID WP_000581792.1
Coordinates 207454..207663 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag RK72_RS01280 Protein ID WP_000138932.1
Coordinates 207675..207968 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RK72_RS01255 202962..204320 - 1359 WP_000611464.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
RK72_RS01260 204335..205405 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
RK72_RS01265 205723..206925 + 1203 WP_001109939.1 rod shape-determining protein RodA -
RK72_RS01270 207189..207326 - 138 WP_000828354.1 hypothetical protein -
RK72_RS01275 207454..207663 - 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
RK72_RS01280 207675..207968 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
RK72_RS01285 208134..209618 + 1485 WP_000571549.1 cardiolipin synthase -
RK72_RS01290 209646..210293 + 648 WP_001187630.1 HD domain-containing protein -
RK72_RS01315 211206..212078 - 873 WP_000725802.1 membrane protein insertase YidC -
RK72_RS01320 212164..212805 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T92978 WP_000581792.1 NZ_CP026063:c207663-207454 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T92978 NZ_CP026063:c207663-207454 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT92978 WP_000138932.1 NZ_CP026063:c207968-207675 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT92978 NZ_CP026063:c207968-207675 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References