Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 3978663..3979264 Replicon chromosome
Accession NZ_CP026062
Organism Proteus mirabilis strain FDAARGOS_81

Toxin (Protein)


Gene name doc Uniprot ID A0A2X2BIG8
Locus tag MC73_RS18660 Protein ID WP_004246497.1
Coordinates 3978663..3979046 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A1Z1SPN9
Locus tag MC73_RS18665 Protein ID WP_004246496.1
Coordinates 3979043..3979264 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MC73_RS18635 3974034..3974492 + 459 WP_004249951.1 GNAT family N-acetyltransferase -
MC73_RS18640 3974588..3975325 - 738 WP_004249950.1 sel1 repeat family protein -
MC73_RS18645 3975434..3976333 + 900 WP_004249949.1 N-acetylmuramic acid 6-phosphate etherase -
MC73_RS18650 3976690..3977928 - 1239 WP_004249948.1 HipA domain-containing protein -
MC73_RS18655 3977941..3978255 - 315 WP_004246498.1 helix-turn-helix domain-containing protein -
MC73_RS18660 3978663..3979046 - 384 WP_004246497.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
MC73_RS18665 3979043..3979264 - 222 WP_004246496.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MC73_RS18670 3979545..3980408 - 864 WP_004249947.1 YicC family protein -
MC73_RS18675 3980535..3981251 + 717 WP_004249946.1 ribonuclease PH -
MC73_RS18680 3981332..3981976 + 645 WP_004249945.1 orotate phosphoribosyltransferase -
MC73_RS18685 3982295..3982900 - 606 WP_004246491.1 nucleoid occlusion factor SlmA -
MC73_RS18690 3983020..3983478 - 459 WP_004246490.1 dUTP diphosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(5-115)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14471.53 Da        Isoelectric Point: 8.5125

>T92973 WP_004246497.1 NZ_CP026062:c3979046-3978663 [Proteus mirabilis]
MIWVSAQEVIAFHDRILQRFPGVAGMSDPGRAEALIYRVQNRKHYEGITDVFELAATYWVAIARGHIFNDGNKRTAFFVT
MTFLYRNGIRIRDTGNMLENLTVEAATGEKTVDQLAKHLQNLVEKTN

Download         Length: 384 bp

>T92973 NZ_CP026062:c3979046-3978663 [Proteus mirabilis]
ATGATATGGGTTAGCGCACAGGAAGTTATCGCTTTCCATGATCGTATATTACAACGTTTCCCAGGTGTGGCCGGTATGTC
CGATCCTGGCAGAGCGGAAGCTCTTATTTACCGGGTGCAAAACCGTAAACATTATGAAGGCATTACAGATGTGTTTGAAC
TGGCAGCAACTTATTGGGTCGCTATCGCTCGAGGGCACATATTTAATGACGGTAATAAACGTACCGCATTTTTTGTGACC
ATGACATTTCTCTATCGTAATGGCATCAGGATCCGCGATACTGGCAATATGCTGGAAAACTTAACAGTAGAAGCAGCTAC
AGGTGAGAAAACCGTCGACCAGTTAGCAAAACATCTACAAAACTTGGTAGAGAAAACTAACTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8260.23 Da        Isoelectric Point: 5.5667

>AT92973 WP_004246496.1 NZ_CP026062:c3979264-3979043 [Proteus mirabilis]
MRTYTSTQARANISEVLDIATHGEPVEITRRDGCSAVVISKTEFESYQNAKLDAEFDMMMQRHGHTVEALTNR

Download         Length: 222 bp

>AT92973 NZ_CP026062:c3979264-3979043 [Proteus mirabilis]
ATGCGTACATATACCTCGACACAAGCCCGAGCCAATATTTCAGAAGTATTAGATATTGCGACCCACGGTGAACCTGTTGA
AATCACCCGCAGAGACGGTTGTTCAGCGGTTGTTATCAGTAAAACTGAATTTGAGTCATACCAGAATGCTAAGCTAGATG
CAGAGTTTGATATGATGATGCAACGTCATGGACATACCGTAGAGGCACTGACAAATCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2X2BIG8

Antitoxin

Source ID Structure
AlphaFold DB A0A1Z1SPN9

References