Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2200144..2200943 Replicon chromosome
Accession NZ_CP026062
Organism Proteus mirabilis strain FDAARGOS_81

Toxin (Protein)


Gene name TacT3 Uniprot ID A0A8E3RD10
Locus tag MC73_RS10445 Protein ID WP_004247966.1
Coordinates 2200144..2200668 (-) Length 175 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID A0A8E3RN02
Locus tag MC73_RS10450 Protein ID WP_036905749.1
Coordinates 2200665..2200943 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MC73_RS10430 2196458..2197399 - 942 WP_036905746.1 glyoxylate/hydroxypyruvate reductase GhrA -
MC73_RS10440 2198363..2200063 + 1701 WP_004247967.1 C4-dicarboxylic acid transporter DauA -
MC73_RS10445 2200144..2200668 - 525 WP_004247966.1 hypothetical protein Toxin
MC73_RS10450 2200665..2200943 - 279 WP_036905749.1 DUF1778 domain-containing protein Antitoxin
MC73_RS10455 2201021..2201950 - 930 WP_036905752.1 TIGR01212 family radical SAM protein -
MC73_RS10460 2201958..2202812 - 855 WP_004242689.1 3-deoxy-8-phosphooctulonate synthase -
MC73_RS10465 2202870..2203685 - 816 WP_004242688.1 invasion regulator SirB1 -
MC73_RS10470 2203663..2204511 - 849 WP_004251398.1 peptide chain release factor N(5)-glutamine methyltransferase -
MC73_RS10475 2204511..2205593 - 1083 WP_004242680.1 peptide chain release factor 1 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(11-87)


Sequences

Toxin        


Download         Length: 175 a.a.        Molecular weight: 19192.12 Da        Isoelectric Point: 9.3561

>T92971 WP_004247966.1 NZ_CP026062:c2200668-2200144 [Proteus mirabilis]
MTIPNWHEEAISKKHNRNGFNCGDAVLNQFLYRHARQNHENGSAKTYLAINNSNNIILGYYSLCPASIEFERTPELIKHG
LARHDIPVFKLARLATDLSVQGKGLGGQLLLAAGRRCLSVASELGGVALLIDAKNERVANWYISYGAIPLLDTPLSLLIS
FKTIYTALSMANKI

Download         Length: 525 bp

>T92971 NZ_CP026062:c2200668-2200144 [Proteus mirabilis]
ATGACAATACCAAATTGGCACGAAGAAGCGATCAGTAAAAAACATAATAGAAATGGATTTAATTGTGGCGATGCAGTACT
AAACCAATTTCTGTATCGCCATGCAAGACAAAATCATGAGAATGGTAGTGCGAAAACATATTTAGCTATCAATAATAGTA
ATAATATTATATTAGGTTATTACAGCTTATGTCCTGCTTCTATTGAGTTCGAAAGAACGCCCGAATTGATCAAACATGGC
TTAGCGCGTCATGATATCCCTGTTTTTAAACTTGCACGACTAGCTACGGATCTATCCGTTCAAGGAAAAGGTTTGGGTGG
GCAATTATTGCTTGCAGCAGGAAGGCGTTGTCTTTCCGTTGCTAGTGAATTGGGAGGCGTTGCTTTACTTATAGATGCTA
AAAATGAACGAGTCGCTAATTGGTATATTAGCTACGGGGCAATACCATTATTAGATACCCCTCTTTCTTTATTAATTTCC
TTTAAAACCATTTATACTGCACTTTCAATGGCAAATAAAATATAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10180.76 Da        Isoelectric Point: 6.3299

>AT92971 WP_036905749.1 NZ_CP026062:c2200943-2200665 [Proteus mirabilis]
MAQALVENSERVSIRITTEDKSLLVRAASLENTNLTEFVLRNIVPVARQVIENNERLKLSGKDTLRVMELLDNPPKPNAK
LLAAAFALPDNA

Download         Length: 279 bp

>AT92971 NZ_CP026062:c2200943-2200665 [Proteus mirabilis]
ATGGCTCAAGCACTAGTAGAAAACAGTGAACGAGTGTCAATTCGTATCACTACAGAAGATAAATCACTGCTGGTTCGTGC
TGCTAGTTTGGAAAATACAAACTTAACAGAGTTTGTACTTCGTAATATTGTACCTGTAGCTCGGCAAGTTATTGAAAATA
ATGAGCGTTTAAAATTATCAGGAAAAGACACATTACGTGTTATGGAACTTTTAGATAATCCACCAAAGCCTAATGCTAAA
CTACTTGCAGCGGCTTTTGCTCTACCGGACAATGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References