Detailed information of TA system TA092970

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-MqsA
• Location: 246286..246985
• Replicon: chromosome
• Accession: NZ_CP026062
• Organism: Proteus mirabilis strain FDAARGOS_81

Toxin (Protein)

• Gene name: relE
• Uniprot ID: B4EZ96
• Locus tag: MC73_RS01245
• Protein ID: WP_004249093.1
• Coordinates: 246599..246985 (-)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B4EZ97
• Locus tag: MC73_RS01240
• Protein ID: WP_004246828.1
• Coordinates: 246286..246606 (-)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MC73_RS01210	241412..241687	-	276	WP_004246820.1	DNA-directed RNA polymerase subunit omega	-
MC73_RS01215	241742..242365	-	624	WP_004246821.1	guanylate kinase	-
MC73_RS01220	242667..243284	-	618	WP_004246822.1	trimeric intracellular cation channel family protein	-
MC73_RS01225	243421..244707	+	1287	WP_017628657.1	DUF3748 domain-containing protein	-
MC73_RS01230	244925..245809	+	885	WP_012368526.1	endonuclease/exonuclease/phosphatase family protein	-
MC73_RS01235	245802..246236	+	435	WP_004246827.1	hypothetical protein	-
MC73_RS01240	246286..246606	-	321	WP_004246828.1	helix-turn-helix domain-containing protein	Antitoxin
MC73_RS01245	246599..246985	-	387	WP_004249093.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MC73_RS01250	247153..249225	-	2073	WP_036904846.1	glycine--tRNA ligase subunit beta	-
MC73_RS01255	249235..250140	-	906	WP_036904849.1	glycine--tRNA ligase subunit alpha	-
MC73_RS01260	250391..250972	+	582	WP_036904852.1	DNA-3-methyladenine glycosylase I	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-125)

Antitoxin

• Cro/C1-type helix-turn-helix domain (53-95)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14294.64 Da
• Isoelectric Point: 10.0642

>T92970 WP_004249093.1 NZ_CP026062:c246985-246599 [Proteus mirabilis]
MVIYKTKMFKNSFKKITLTNAELIAIATEVLAGQFEADLGGGVIKKRACIQGKGKSSGIRTIIFYKQGNNLFFADGWKKS
SLSSKKTKEITDDELESYKDLAKDLFNANQNKIDKMIALGLLTEVKYD

Nucleotide

• Length: 387 bp

>T92970 NZ_CP026062:c246985-246599 [Proteus mirabilis]
ATGGTTATTTATAAAACAAAGATGTTCAAAAATAGTTTCAAAAAAATAACGCTTACGAATGCAGAACTAATAGCTATCGC
TACCGAAGTCCTTGCAGGACAATTTGAGGCAGATCTAGGTGGTGGTGTTATCAAGAAACGTGCCTGTATCCAAGGAAAAG
GTAAAAGTAGCGGAATTAGAACAATTATATTTTATAAGCAAGGGAATAATTTATTCTTTGCTGATGGTTGGAAAAAATCG
AGTTTAAGCTCTAAAAAAACCAAAGAGATCACAGATGATGAACTTGAGTCCTATAAAGATCTAGCAAAAGATCTCTTCAA
TGCAAATCAAAATAAAATAGATAAAATGATTGCACTAGGCCTTTTAACAGAGGTTAAATATGACTGA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 12126.21 Da
• Isoelectric Point: 10.4411

>AT92970 WP_004246828.1 NZ_CP026062:c246606-246286 [Proteus mirabilis]
MTDKMKEMLKFAQEMEDAGVTDGSTTKRIAARIKAKELQAKYKHPTPMTGEDIKRIREQNNISQSSLALILNMTKESVSK
WERNEIKPNGAALRLLHLIDKKILFI

Nucleotide

• Length: 321 bp

>AT92970 NZ_CP026062:c246606-246286 [Proteus mirabilis]
ATGACTGATAAAATGAAAGAAATGCTAAAATTTGCACAAGAAATGGAAGATGCAGGAGTCACTGATGGCAGTACAACTAA
ACGTATTGCCGCCAGAATAAAAGCGAAAGAATTACAAGCTAAGTATAAACATCCTACCCCTATGACAGGTGAAGATATAA
AAAGGATCCGTGAGCAAAATAATATCTCTCAATCTTCCCTTGCTTTGATATTGAATATGACTAAAGAAAGCGTTTCTAAG
TGGGAAAGAAACGAAATTAAGCCCAATGGTGCAGCACTACGACTTCTTCATTTAATAGATAAAAAAATATTATTCATCTA
G

Structures

Toxin

• AlphaFold DB: B4EZ96

Antitoxin

• AlphaFold DB: B4EZ97