Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 3846840..3847441 Replicon chromosome
Accession NZ_CP026059
Organism Proteus mirabilis strain FDAARGOS_80

Toxin (Protein)


Gene name doc Uniprot ID A0A1Z1SQZ4
Locus tag MC72_RS17720 Protein ID WP_036895893.1
Coordinates 3846840..3847223 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A1Z1SPN9
Locus tag MC72_RS17725 Protein ID WP_004246496.1
Coordinates 3847220..3847441 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MC72_RS17695 3842138..3842707 + 570 WP_004249768.1 methyltransferase -
MC72_RS17700 3842763..3844250 - 1488 WP_036895884.1 PLP-dependent aminotransferase family protein -
MC72_RS17705 3844379..3844837 + 459 WP_036895886.1 GNAT family N-acetyltransferase -
MC72_RS17710 3844933..3845670 - 738 WP_036895888.1 sel1 repeat family protein -
MC72_RS17715 3845779..3846678 + 900 WP_036895890.1 N-acetylmuramic acid 6-phosphate etherase -
MC72_RS17720 3846840..3847223 - 384 WP_036895893.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
MC72_RS17725 3847220..3847441 - 222 WP_004246496.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MC72_RS17730 3847663..3848526 - 864 WP_004249947.1 YicC family protein -
MC72_RS17735 3848653..3849369 + 717 WP_004249760.1 ribonuclease PH -
MC72_RS17740 3849451..3850095 + 645 WP_004246493.1 orotate phosphoribosyltransferase -
MC72_RS17745 3850414..3851019 - 606 WP_004246491.1 nucleoid occlusion factor SlmA -
MC72_RS17750 3851139..3851597 - 459 WP_004246490.1 dUTP diphosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(2-125)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14518.52 Da        Isoelectric Point: 8.4945

>T92969 WP_036895893.1 NZ_CP026059:c3847223-3846840 [Proteus mirabilis]
MIWVSAQEVIAFHDRILQRFPGVAGMSDPGRAEALIYRVQNRKHYEGITDVFELAATYWVAIARGRIFNDGNKRTAFFVT
MTFLYRNGIRIRDTDNTLENLTVEAATGEKTVDQLAKHLQNLVEKTN

Download         Length: 384 bp

>T92969 NZ_CP026059:c3847223-3846840 [Proteus mirabilis]
ATGATATGGGTTAGCGCACAGGAAGTTATCGCTTTCCATGATCGTATATTACAACGTTTCCCAGGTGTGGCCGGTATGTC
CGATCCTGGCAGAGCGGAAGCTCTTATTTACCGGGTGCAAAACCGTAAACATTATGAAGGCATTACAGATGTGTTTGAAC
TGGCAGCAACTTATTGGGTCGCTATCGCTCGAGGGCGCATATTTAATGACGGTAATAAACGTACCGCATTTTTTGTGACC
ATGACATTTCTCTATCGTAATGGCATCAGGATCCGCGATACCGACAATACGCTGGAAAACTTAACAGTGGAAGCGGCTAC
AGGTGAGAAAACCGTCGACCAGTTAGCAAAACATCTACAAAACTTGGTAGAGAAAACTAACTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8260.23 Da        Isoelectric Point: 5.5667

>AT92969 WP_004246496.1 NZ_CP026059:c3847441-3847220 [Proteus mirabilis]
MRTYTSTQARANISEVLDIATHGEPVEITRRDGCSAVVISKTEFESYQNAKLDAEFDMMMQRHGHTVEALTNR

Download         Length: 222 bp

>AT92969 NZ_CP026059:c3847441-3847220 [Proteus mirabilis]
ATGCGTACATATACCTCGACACAAGCCCGAGCCAATATCTCAGAAGTATTAGATATTGCGACCCACGGTGAACCTGTTGA
AATCACCCGCAGAGACGGTTGTTCAGCAGTTGTTATCAGTAAAACTGAATTTGAGTCATACCAGAATGCTAAGCTAGATG
CAGAGTTTGATATGATGATGCAACGTCATGGACATACCGTAGAGGCGCTGACAAATCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Z1SQZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A1Z1SPN9

References