Detailed information of TA system TA092967

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-MqsA
• Location: 3530626..3531325
• Replicon: chromosome
• Accession: NZ_CP026059
• Organism: Proteus mirabilis strain FDAARGOS_80

Toxin (Protein)

• Gene name: relE
• Uniprot ID: B4EZ96
• Locus tag: MC72_RS16320
• Protein ID: WP_004249093.1
• Coordinates: 3530626..3531012 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B4EZ97
• Locus tag: MC72_RS16325
• Protein ID: WP_004246828.1
• Coordinates: 3531005..3531325 (+)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MC72_RS16305	3526645..3527226	-	582	WP_012368524.1	DNA-3-methyladenine glycosylase I	-
MC72_RS16310	3527477..3528382	+	906	WP_004246832.1	glycine--tRNA ligase subunit alpha	-
MC72_RS16315	3528392..3530464	+	2073	WP_004246830.1	glycine--tRNA ligase subunit beta	-
MC72_RS16320	3530626..3531012	+	387	WP_004249093.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MC72_RS16325	3531005..3531325	+	321	WP_004246828.1	helix-turn-helix domain-containing protein	Antitoxin
MC72_RS16330	3531374..3531808	-	435	WP_004246827.1	hypothetical protein	-
MC72_RS16335	3531801..3532685	-	885	WP_012368526.1	endonuclease/exonuclease/phosphatase family protein	-
MC72_RS16340	3532900..3534186	-	1287	WP_036895746.1	DUF3748 domain-containing protein	-
MC72_RS16345	3534323..3534940	+	618	WP_004246822.1	trimeric intracellular cation channel family protein	-
MC72_RS16350	3535241..3535864	+	624	WP_004246821.1	guanylate kinase	-
MC72_RS16355	3535919..3536194	+	276	WP_004246820.1	DNA-directed RNA polymerase subunit omega	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-125)

Antitoxin

• Cro/C1-type helix-turn-helix domain (53-95)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14294.64 Da
• Isoelectric Point: 10.0642

>T92967 WP_004249093.1 NZ_CP026059:3530626-3531012 [Proteus mirabilis]
MVIYKTKMFKNSFKKITLTNAELIAIATEVLAGQFEADLGGGVIKKRACIQGKGKSSGIRTIIFYKQGNNLFFADGWKKS
SLSSKKTKEITDDELESYKDLAKDLFNANQNKIDKMIALGLLTEVKYD

Nucleotide

• Length: 387 bp

>T92967 NZ_CP026059:3530626-3531012 [Proteus mirabilis]
ATGGTTATTTATAAAACAAAGATGTTCAAAAATAGTTTCAAAAAAATAACGCTTACGAATGCAGAACTAATAGCTATCGC
TACCGAAGTCCTTGCAGGACAATTTGAGGCAGATCTAGGTGGTGGTGTTATCAAGAAACGTGCCTGTATCCAAGGAAAAG
GTAAAAGTAGCGGAATTAGAACAATTATATTTTATAAGCAAGGGAATAATTTATTCTTTGCTGATGGTTGGAAAAAATCG
AGTTTAAGCTCTAAAAAAACCAAAGAGATCACAGATGATGAACTTGAGTCCTATAAAGATCTAGCAAAAGATCTCTTCAA
TGCAAATCAAAATAAAATAGATAAAATGATTGCACTAGGCCTTTTAACAGAGGTTAAATATGACTGA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 12126.21 Da
• Isoelectric Point: 10.4411

>AT92967 WP_004246828.1 NZ_CP026059:3531005-3531325 [Proteus mirabilis]
MTDKMKEMLKFAQEMEDAGVTDGSTTKRIAARIKAKELQAKYKHPTPMTGEDIKRIREQNNISQSSLALILNMTKESVSK
WERNEIKPNGAALRLLHLIDKKILFI

Nucleotide

• Length: 321 bp

>AT92967 NZ_CP026059:3531005-3531325 [Proteus mirabilis]
ATGACTGATAAAATGAAAGAAATGCTAAAATTTGCACAAGAAATGGAAGATGCAGGAGTCACTGATGGCAGTACAACTAA
ACGTATTGCCGCCAGAATAAAAGCGAAAGAATTACAAGCTAAGTATAAACATCCTACCCCTATGACAGGTGAAGATATAA
AAAGGATCCGTGAGCAAAATAATATCTCTCAATCTTCCCTTGCTTTGATATTGAATATGACTAAAGAAAGCGTTTCTAAG
TGGGAAAGAAACGAAATTAAGCCCAATGGTGCAGCACTACGACTTCTTCATTTAATAGATAAAAAAATATTATTCATCTA
G

Structures

Toxin

• AlphaFold DB: B4EZ96

Antitoxin

• AlphaFold DB: B4EZ97