Detailed information of TA system TA092965

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1300029..1300674
• Replicon: chromosome
• Accession: NZ_CP026059
• Organism: Proteus mirabilis strain FDAARGOS_80

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: B4ET86
• Locus tag: MC72_RS05935
• Protein ID: WP_004247035.1
• Coordinates: 1300489..1300674 (-)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: B4ET85
• Locus tag: MC72_RS05930
• Protein ID: WP_004247034.1
• Coordinates: 1300029..1300442 (-)
• Length: 138 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MC72_RS19000	1295581..1295739	-	159	WP_004247025.1	hypothetical protein	-
MC72_RS19005	1296191..1296367	+	177	WP_180949079.1	hypothetical protein	-
MC72_RS05900	1296538..1297284	-	747	WP_036894646.1	methyltransferase domain-containing protein	-
MC72_RS05910	1298134..1298712	+	579	WP_004247030.1	alpha/beta hydrolase	-
MC72_RS05915	1298825..1299118	-	294	Protein_1133	LysE family transporter	-
MC72_RS05925	1299436..1299933	-	498	Protein_1134	response regulator	-
MC72_RS05930	1300029..1300442	-	414	WP_004247034.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
MC72_RS05935	1300489..1300674	-	186	WP_004247035.1	type II toxin-antitoxin system HicA family toxin	Toxin
MC72_RS05940	1300785..1301555	+	771	Protein_1137	DUF1073 domain-containing protein	-
MC72_RS05950	1302114..1302664	-	551	Protein_1138	PH domain-containing protein	-
MC72_RS05955	1302728..1303042	-	315	WP_012367751.1	hypothetical protein	-
MC72_RS05965	1303459..1305192	-	1734	WP_036894652.1	LPS biosynthesis-modulating metalloenzyme YejM	-
MC72_RS05970	1305216..1305443	-	228	WP_004247042.1	YejL family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1300029..1312665	12636

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 7049.30 Da
• Isoelectric Point: 10.9659

>T92965 WP_004247035.1 NZ_CP026059:c1300674-1300489 [Proteus mirabilis]
MKSSELIKLLEKNGWILDRIKGSHHQFTHPDFSFVVTVPHPRKDLKKGTLNQIIKSAKLKN

Nucleotide

• Length: 186 bp

>T92965 NZ_CP026059:c1300674-1300489 [Proteus mirabilis]
TTGAAAAGTTCGGAACTGATTAAGTTGTTAGAAAAAAACGGATGGATACTTGATAGAATAAAAGGAAGTCATCATCAATT
TACTCACCCTGATTTTTCTTTTGTTGTAACAGTACCGCATCCAAGAAAAGATTTAAAAAAAGGAACATTAAATCAAATTA
TTAAAAGTGCCAAACTGAAAAATTAA

Antitoxin

Protein

• Length: 138 a.a.
• Molecular weight: 15251.98 Da
• Isoelectric Point: 4.3830

>AT92965 WP_004247034.1 NZ_CP026059:c1300442-1300029 [Proteus mirabilis]
MLYPAFIEIDEDGSASGWFPDIDGCIFAGDSIEEAHADARSAIDAHFELLSEKGLDIPSPKSQQEHLINSSGDYNNGIWL
LVDVDMDKYDGRAERINITLPHRLLSRIDTIVKTNPEYGSRSGFIATATRKELQKNI

Nucleotide

• Length: 414 bp

>AT92965 NZ_CP026059:c1300442-1300029 [Proteus mirabilis]
ATGTTATATCCAGCCTTTATTGAAATTGATGAAGATGGTAGCGCAAGTGGCTGGTTCCCTGATATTGATGGTTGCATCTT
TGCGGGGGACAGTATTGAAGAAGCTCACGCAGATGCGAGGAGCGCTATTGATGCCCATTTTGAATTGTTAAGCGAGAAGG
GTTTAGATATCCCCTCTCCAAAATCTCAACAAGAGCATTTAATTAATTCTAGTGGTGATTACAATAATGGAATATGGCTT
TTAGTTGATGTTGATATGGATAAATACGACGGACGAGCAGAGCGTATTAATATCACATTGCCACATCGATTATTGAGTCG
CATCGATACTATCGTAAAAACAAATCCTGAATATGGGAGTCGTAGCGGATTTATTGCCACAGCAACCCGTAAAGAACTCC
AAAAGAATATTTAA

Structures

Toxin

• AlphaFold DB: B4ET86

Antitoxin

• AlphaFold DB: B4ET85