Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 698285..699081 Replicon chromosome
Accession NZ_CP026059
Organism Proteus mirabilis strain FDAARGOS_80

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag MC72_RS03225 Protein ID WP_036894284.1
Coordinates 698569..699081 (+) Length 171 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID -
Locus tag MC72_RS03220 Protein ID WP_036894282.1
Coordinates 698285..698572 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MC72_RS03210 694782..696083 + 1302 WP_004244982.1 phosphopyruvate hydratase -
MC72_RS03215 696403..697785 + 1383 WP_004247295.1 DASS family sodium-coupled anion symporter -
MC72_RS03220 698285..698572 + 288 WP_036894282.1 DUF1778 domain-containing protein Antitoxin
MC72_RS03225 698569..699081 + 513 WP_036894284.1 GNAT family N-acetyltransferase Toxin
MC72_RS03230 699260..700594 - 1335 WP_004244978.1 murein transglycosylase D -
MC72_RS03235 700668..701423 - 756 WP_004244977.1 hydroxyacylglutathione hydrolase -
MC72_RS03240 701461..702174 + 714 WP_017827399.1 methyltransferase domain-containing protein -
MC72_RS03245 702199..702678 - 480 WP_004244975.1 ribonuclease HI -
MC72_RS03250 702744..703502 + 759 WP_017628297.1 DNA polymerase III subunit epsilon -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(32-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-87)


Sequences

Toxin        


Download         Length: 171 a.a.        Molecular weight: 18393.37 Da        Isoelectric Point: 9.5973

>T92964 WP_036894284.1 NZ_CP026059:698569-699081 [Proteus mirabilis]
MTLKLTAPEPLKSVHLLEGFSSGEEALDLWLKNRAMSNQNSGASRTFVTTSDNQVMGYYALSTGVISTNQAVGRFRRNMP
TDIPVILLGRLAVDTRAKGLGIGRGLVKDACHRVIQASGLVGIRGVVVHALTDDAKRFYEHIGFLPSPLDPMMLMITLSD
LQLAMGISPN

Download         Length: 513 bp

>T92964 NZ_CP026059:698569-699081 [Proteus mirabilis]
ATGACATTGAAGCTAACAGCACCTGAACCACTCAAATCAGTCCATCTGCTGGAGGGTTTTTCCTCCGGAGAAGAGGCTTT
AGATCTCTGGCTAAAAAACCGGGCAATGAGTAATCAAAACTCTGGTGCGTCGCGCACTTTTGTGACCACTTCGGATAACC
AGGTAATGGGGTATTATGCCTTGTCCACAGGGGTCATAAGCACCAATCAAGCCGTTGGTCGATTCCGCCGTAATATGCCC
ACCGACATACCCGTCATTCTACTTGGCAGGCTGGCGGTTGATACAAGGGCTAAAGGTCTTGGGATCGGAAGAGGACTTGT
TAAGGATGCCTGTCATCGCGTTATTCAGGCATCAGGGCTGGTGGGCATTAGAGGGGTGGTGGTTCACGCCCTTACTGACG
ATGCAAAACGGTTCTATGAGCATATTGGCTTCTTGCCTTCGCCGCTCGACCCGATGATGCTGATGATAACGCTTAGCGAT
CTGCAACTCGCTATGGGCATTTCCCCGAACTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10717.15 Da        Isoelectric Point: 5.1972

>AT92964 WP_036894282.1 NZ_CP026059:698285-698572 [Proteus mirabilis]
MPTQNDVSVTRSSLNLRIKPEDKILIDRAANAVGKNRTEFVLEAARRAAEETLADLRVINVSPEVYQEFISQLDSAPESN
EALRKTMMSKSPWEK

Download         Length: 288 bp

>AT92964 NZ_CP026059:698285-698572 [Proteus mirabilis]
ATGCCAACTCAAAATGATGTGAGCGTAACACGTTCATCACTGAACCTGAGAATAAAGCCGGAAGATAAAATTCTGATCGA
CCGTGCCGCTAATGCAGTGGGGAAAAACCGTACCGAGTTTGTTCTGGAAGCTGCTCGACGTGCAGCTGAAGAAACGCTGG
CAGATCTGCGAGTCATTAACGTCAGTCCCGAAGTTTACCAGGAATTTATTAGCCAGCTTGATTCAGCGCCTGAGAGCAAT
GAGGCACTACGAAAAACAATGATGTCTAAATCCCCTTGGGAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References