Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 548718..549378 Replicon chromosome
Accession NZ_CP026059
Organism Proteus mirabilis strain FDAARGOS_80

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MC72_RS02565 Protein ID WP_004245133.1
Coordinates 548718..549143 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A8E3RLN2
Locus tag MC72_RS02570 Protein ID WP_004245128.1
Coordinates 549136..549378 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MC72_RS02535 544015..544464 + 450 WP_004245139.1 transcriptional regulator NrdR -
MC72_RS02540 544513..545670 + 1158 WP_004245138.1 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD -
MC72_RS02545 545883..546353 + 471 WP_004245137.1 6,7-dimethyl-8-ribityllumazine synthase -
MC72_RS02550 546382..546795 + 414 WP_004245136.1 transcription antitermination factor NusB -
MC72_RS02555 546889..547869 + 981 WP_004245135.1 thiamine-phosphate kinase -
MC72_RS02560 547955..548290 - 336 WP_004245134.1 phnA family protein -
MC72_RS02565 548718..549143 - 426 WP_004245133.1 type II toxin-antitoxin system VapC family toxin Toxin
MC72_RS02570 549136..549378 - 243 WP_004245128.1 hypothetical protein Antitoxin
MC72_RS02575 549494..550501 - 1008 WP_012367471.1 ribose operon transcriptional repressor RbsR -
MC72_RS02580 550506..551432 - 927 WP_004245126.1 ribokinase -
MC72_RS02585 551510..552400 - 891 WP_004245125.1 ribose ABC transporter substrate-binding protein RbsB -
MC72_RS02590 552440..553405 - 966 WP_004245124.1 ribose ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-125)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15924.18 Da        Isoelectric Point: 6.4879

>T92963 WP_004245133.1 NZ_CP026059:c549143-548718 [Proteus mirabilis]
MIKYLLDTNIVIFTIKRKPEFLLPKFNQHAEQLAISTITLAELIFGAEKSVNPAKNLATVNDFVSRLTVLSYDDLAAFHY
GDIRATLEKQGKRIGDNDLHIAAHARSKGLIVVTNNTREFERVDGLRIEDWTVINSDPQTD

Download         Length: 426 bp

>T92963 NZ_CP026059:c549143-548718 [Proteus mirabilis]
ATGATTAAATACCTATTAGATACAAATATTGTTATATTCACTATTAAACGCAAGCCTGAGTTTTTATTACCAAAATTCAA
CCAACATGCTGAACAATTAGCTATTTCTACAATTACACTCGCTGAGCTCATTTTTGGTGCTGAAAAAAGTGTAAATCCAG
CCAAAAACTTAGCTACGGTTAACGACTTTGTTTCTCGACTGACTGTTTTATCTTACGATGACTTAGCAGCTTTTCATTAT
GGAGACATTAGAGCAACACTAGAAAAACAGGGAAAACGCATTGGTGATAACGACTTACATATAGCAGCACATGCTAGAAG
TAAGGGGCTAATAGTCGTTACCAATAATACTCGAGAATTTGAAAGAGTTGATGGTTTAAGAATTGAGGATTGGACCGTTA
TTAACTCAGACCCCCAAACTGATTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9390.48 Da        Isoelectric Point: 4.6182

>AT92963 WP_004245128.1 NZ_CP026059:c549378-549136 [Proteus mirabilis]
MIQYGKVFMSNRTQNVRLPAETRFPDDVKEVFVRVKGKERIITPIQNAWDSFFLSEKSVTDDFLSERPDQATSERESFDD

Download         Length: 243 bp

>AT92963 NZ_CP026059:c549378-549136 [Proteus mirabilis]
ATGATCCAGTATGGCAAAGTATTTATGAGCAATAGAACACAAAATGTTCGATTACCCGCTGAGACTCGATTTCCGGATGA
TGTAAAAGAAGTTTTTGTTCGCGTCAAAGGCAAAGAGAGAATAATCACACCTATACAAAATGCATGGGATAGCTTTTTCT
TATCAGAAAAGTCTGTAACAGATGATTTCTTATCTGAAAGGCCTGATCAAGCCACAAGTGAAAGAGAATCCTTTGATGAT
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References